Journal
NATURAL PRODUCT RESEARCH
Volume 26, Issue 11, Pages 1012-1015Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2010.535000
Keywords
antimalarial activity; Xylocarpus granatum medicinal plant
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Funding
- Ministry of Earth Sciences, Government of India, New Delhi
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The antimalarial activity of Xylocarpus granatum fruits and their active constituents gedunin and xyloccensin-I were investigated using an in vitro model in this study. The chloroform fraction of X. granatum fruits was found to show promising antimalarial activity using an in vitro model of Plasmodium falciparum. On purification of the active fraction, four pure compounds were isolated and characterised, namely gedunin, photogedunin, xyloccensin-I and palmitic acid. Out of these only gedunin and xyloccensin-I were found to show activity equivalent to the parent active fraction in vitro model.
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