Journal
NATURAL PRODUCT RESEARCH
Volume 26, Issue 17, Pages 1654-1658Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2011.589386
Keywords
Curcuma longa; turmerin; alpha-glucosidase; alpha-amylase; antidiabetic; antioxidant
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Funding
- Council for Scientific and Industrial Research, India
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A wide range of proteinaceous inhibitors are present in plants to protect themselves from hydrolytic enzymes. In this study, turmerin, a water-soluble peptide in turmeric rhizomes, was evaluated for its inhibitory potential against glucosidase and its antioxidant (AO) capacity. Turmerin inhibited alpha-amylase and alpha-glucosidase activities with IC50 values 31 and 192 mu g mL(-1), respectively. Under the experimental conditions, those values for a standard glucosidase inhibitor, acarbose, were 81 and 296 mu g mL(-1), respectively. The AO capacity of turmerin was evaluated using in vitro assay systems. Turmerin showed good DPPH (IC50 29 mu g mL(-1)) and superoxide (IC50 48 mu g mL(-1)) and moderate ABTS (IC50 83 mu g mL(-1)) radical scavenging and Fe(II) chelation (IC50 101 mu g mL(-1)) capacities. The inhibitory potential showed by turmerin against enzymes linked to type 2 diabetes, as well as its moderate AO capacity, could rationalise the traditional usage of turmeric rhizome preparations against diabetes.
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