4.4 Article

Antimicrobial, antileishmanial and cytotoxic compounds from Piper chaba

Journal

NATURAL PRODUCT RESEARCH
Volume 26, Issue 11, Pages 979-986

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2010.535166

Keywords

Piper chaba; antimicrobial; antileishmanial; cytotoxicity

Funding

  1. National Research Foundation of Korea (NRF)
  2. Ministry of Education, Science and Technology [2009-0094061, 2009-0341]
  3. National Research Foundation of Korea [2009-0094061] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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The petroleum ether and chloroform extracts of the root of Piper chaba showed antimicrobial, antileishmanial and cytotoxic activities. Further bioactivity-guided fractionation led to the isolation of Bornyl piperate (1), piperlonguminine (2) and piperine (3). This is the first report of isolation of compounds (1) and (2) from P. chaba. It was observed that the isolated compounds (1 and 2) showed potent antifungal activity when compared with standard drug Nystatin, and significant cytotoxic activity with the IC50 values of 0.76 and 0.83 mu g mL(-1), respectively. These compounds were also found to have weak antibacterial and antileishmanial activities. This is the first report about the antileishmanial activity of Piper isolates.

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