Journal
NATURAL PRODUCT RESEARCH
Volume 26, Issue 23, Pages 2227-2231Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2011.643885
Keywords
Cedrus libani; Cedrus atlantica; Cedrus deodara; antiproliferative activity; terpenes; GC/MS
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There are four kinds of Cedar: Cedrus libani naturally occurring in Lebanon, Syria and Turkey, Cedrus atlantica in Morocco and Algeria, Cedrus brevefolia in Cyprus Island and Cedrus deodara which is distributed in Himalayan Mountains. Wood essential oils obtained from C. libani, C. atlantica and C. deodara were tested for the inhibition of K562 cell proliferation and for the induction of erythroid differentiation. The wood essential oils of C. libani, C. atlantica and C. deodara inhibited the proliferation of the K562 cell line exhibiting IC50 values 23.38 +/- 1.7, 59.37 +/- 2.6 and 37.09 +/- 1.4 mu g mL(-1), respectively. Meanwhile, C. libani wood oils induced a percentage of erythroid differentiation of 15 +/- 2% at concentration 5 mu g mL(-1). Cedrus deodara wood oil indicated a percentage of erythroid differentiation of 20 +/- 2% at concentration 25 mu g mL(-1) and C. atlantica wood oils showed a percentage of erythroid differentiation of 12 +/- 1.8% at concentration 10 mu g mL(-1).
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