Journal
NATURAL PRODUCT RESEARCH
Volume 25, Issue 16, Pages 1505-1511Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786410903211235
Keywords
marine bryozoan; Bugula neritina; steroid; cytotoxicity
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Funding
- National High Technology Research and Development Program of China (863 Project) [2007AA09Z401]
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Two new oxygenated sterols, 3 beta,24(S)-dihydroxycholesta-5,25-dien-7-one (1) and 3 beta,25-dihydroxycholesta-5,23-dien-7-one (2), were isolated from the marine bryozoan Bugula neritina. Their chemical structures were established on the basis of spectroscopic analysis. Both compounds exhibited cytotoxicity to three human cancer cell lines (HepG2, HT-29 and NCI-H460), with IC50 values between 22.58 and 53.41 mu g mL(-1).
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