Journal
NATURAL PRODUCT RESEARCH
Volume 26, Issue 18, Pages 1682-1686Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2011.592836
Keywords
Swertia chirayita; free radical-scavenging activity; Folin-Ciocalteu reagent; total phenolic content; DPPH; xanthone
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Funding
- University of Delhi, Department of Science and Technology, New Delhi
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An activity-guided isolation and purification process was used to identify the DPPH (l, l-diphenyl-2-picrylhydrazyl) radical-scavenging components of Swertia chirayita. A dry, whole plant of S. chirayita was extracted with different solvents and tested for its DPPH radical-scavenging activity. The acetone : water (8 : 2) extract showed the highest total phenolic content (TPC) and DPPH radical-scavenging activity, which was column chromatographed to obtain decussatin, swertianin, bellidifolin, isobellidifolin, amarogentin, swertianolin and mangiferin as active components. Good correlation was observed between TPC and DPPH scavenging activity among the extracts. The unique structure of xanthones, including the catecholic moiety and the completely conjugated system, enables them to be promising antioxidants.
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