Journal
NATURAL PRODUCT RESEARCH
Volume 25, Issue 11, Pages 1110-1114Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2010.541883
Keywords
Nerium oleander; high fat diet; cardioprotective; hypolipidemic; lipids; cardiac glycosides
Categories
Funding
- Drugs and Pharmaceutical Division of Department of Science and Technology, Government of India
Ask authors/readers for more resources
Nerium oleander Linn. (NO), an evergreen shrub, is used in folklore medicine as a cardiotonic and exhibits a wide spectrum of bioactivities. Herein, the hypolipidemic potential of the ethanolic extract of flowers of Nerium oleander (ENO) in a minimal dose was assessed. A high fat diet (HFD) resulted in a significant increase in cardiac lipids and lipoproteins and an increase in body weight gain. Simultaneous treatment with ENO significantly lowered the increase in body weight gain, lipid and lipoprotein levels, with a concomitant increase in HDL in the plasma and heart when compared to HFD-fed rats. Likewise, the activities of lipolytic enzymes were also upheld by the ENO treatment in the heart compared to HFD-fed rats. The above findings highlight the possible mechanism of N. oleander as a hypolipidemic agent in its use in folklore medicine as a cardiotonic.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available