Journal
NATURAL PRODUCT RESEARCH
Volume 24, Issue 6, Pages 515-520Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786410802271587
Keywords
Ptagiochasm intermedlum L; Aytoniaceae; macrocyclic bis(bibenzyls); riccardin C; antifungal activity; combined effect
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Funding
- National Natural Science Foundation of China [30672531]
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Six macrocyclic bis(bibenzyls) were obtained from the Chinese liverwort Ptagiochasm intermedlum L., and their structures were elucidated as pakyonol (1), neomarchantin A (2), isoriccardin C (3), marchantin H (4), riccardin F (5) and riccardin C (6) on the basis of spectroscopic data and comparison with known compounds. Among them, compounds 3-5 were isolated from this liverwort species for the first time. They possessed in vitro antifungal properties against the fluconazole-sensitive and resistant strains of Candida albicans, with minimum inhibitory concentrations (MICs) ranging from 32 to 512 mu g mL-1. Furthermore, riccardin C was also demonstrated to act as a fungal resistance modifying agent when its combined effect with fluconazole on three resistant strains of C. albicans was investigated. The synergistic or additive activity of riccardin C caused dramatically reduced MICs of fluconazole by at most 256-fold.
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