Journal
NATURAL PRODUCT RESEARCH
Volume 23, Issue 12, Pages 1144-1150Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786410902726241
Keywords
Trypanosoma cruzi; Leishmania infantum; Enantia chlorantha; palmatine; inhibitory effect
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Funding
- International Foundation of Science (IFS)
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In an attempt to establish the components responsible for the use of Enantia chlorantha against cutaneous leishmaniasis in local traditional medicine, a well-known palmatine has been isolated in substantial amounts from a methanolic bark extract of this plant species. Palmatine therein obtained exhibited a significant inhibitory activity on growth of both Trypanosoma cruzi (IC50 0.068 mu M) and Leishmania infantum (IC50 0.79 mu M).
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