Journal
NATURAL PRODUCT RESEARCH
Volume 23, Issue 18, Pages 1677-1688Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786410802181745
Keywords
derricin; lonchocarpin; Lonchocarpus sericeus; paw oedema; pentoxifylline; phosphodiesterase
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Funding
- Brazilian National Research Council (CNPq)
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The acute anti-inflammatory properties of a fraction rich in the chalcones lonchocarpin and derricin, from the roots of Lonchocarpus sericeus (HFLS), were studied for the first time, using a paw oedema model induced in rats by various stimuli. Results showed that HFLS (100 and 200mg kg(-1), i.p.) was ineffective in inhibiting dextran-induced paw oedema. The HFLS (200mg kg(-1), p.o. or i.p.) also failed to inhibit the bradykinin-induced oedema. In the yeast-elicited oedema, the HFLS (200mg kg(-1), i.p.) caused inhibitions ranging from 42 to 59% in the first to fourth hours. Orally administered HFLS (200 mg kg(-1)) was active only in the second (27%) and fourth (32%) hours after yeast injection. It was observed that HFLS (50, 100 and 200 mg kg(-1), i.p.) showed inhibitions of 34, 57 and 74%, respectively, in the third hour for the carrageenan-induced oedema. The inhibition was smaller when the HFLS (100 and 200mg kg(-1)) was administered orally. The effect of the HFLS (20 mg kg(-1), i.p.) in the carrageenan-induced oedema was not modified by the L-NAME, but the association of pentoxifylline and HFLS increased its effect, suggesting an involvement of the PDE enzyme.
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