Journal
NATURAL PRODUCT RESEARCH
Volume 23, Issue 1, Pages 51-59Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786410701782544
Keywords
anti-ulcer activitiy; leaves; Wilbrandia ebracteata; Cucurbitaceae; C-glycosylflavones
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Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao o Paulo - FAPESP
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico - CNPq
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Leaf fractions of Wilbrandia ebracteata were investigated for anti-ulcerogenic effects in ethanol and indomethacin-induced gastric ulcer assays in mice. Protective anti-ulcer effects were detected only in the ethanol-induced ulcer assay effects after pre-treatment with MeOH extract, MeOH chlorophyll-free, chlorophyll residue, HEX, DCM, aqueous MeOH fraction, ethyl acetate (EtOAc) and aqueous fractions. A potent anti-ulcerogenic effect was determined after pre-treatment of animals with EtOAc fraction, which was fractionated for isolation of active constituents. Seven flavonoids, 3',4',5,6,7,8-hexahydroxyflavonol, orientin, isoorientin, vitexin, isovitexin, luteolin, 6-methoxi-luteolin were isolated from the leaves of W. ebracteata (Cucurbitaceae) by chromatographic methods and identified by their spectral data. The data suggest that flavonoids are active anti-ulcerogenic compounds from leaves of W. ebracteata. The ability of scavenging free radicals was evaluated by DPPH reduction assay by TLC of flavonoids isolated.
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