Journal
NATURAL PRODUCT RESEARCH
Volume 23, Issue 12, Pages 1095-1107Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786410802362352
Keywords
Streptomyces sp; TN58; purification; chemical structure; rhamnopyranoside derivatives; antimicrobial activities
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Funding
- Tunisian Government [LEMP-CBS]
- Department of Organic and Biomolecular Chemistry of the University of Gottingen, Germany
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Extraction of 25 L fermentation broth of the newly isolated Streptomyces sp. strain TN58 and various separation and purification steps led to the isolation of five bioactive metabolites, namely brevianamide F (C1), reported from a streptomycete for the first time, N-acetyltryptamine (C2), thiazolidomycin (C3), and two rhamnopyranosides (C4 and C5). These two rhamnopyranosides were produced directly, without precursor addition. The chemical structure of these five active compounds was established on the basis of 1H, 13C/APT and 2D NMR spectra, ESI and EI-MS data, and by comparison with data from the literature. According to the biological studies, we show in this work that the compounds C1, C2, C4 and C5 possess antimicrobial activities.
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