Journal
NATURAL PRODUCT RESEARCH
Volume 23, Issue 3, Pages 203-207Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786410600906970
Keywords
marine-derived fungus; Aspergillus fumigatus; gliotoxin analogues; cytotoxic activity
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Funding
- Chinese National Natural Science fund [30470196, 30472136]
- Chinese National Programs for High Technology Research and Development [2003AA624020]
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A new gliotoxin analogue (1), as well as four known compounds gliotoxin (2), bisdethiobis (methylthio) gliotoxin (3), bis-N-norgliovictin (4) and didehydrobisdethiobis (methylthio) gliotoxin (5), were isolated from a culture of marine-derived fungus Aspergillus fumigatus Fres. The structure of 1 was determined on the basis of spectroscopic methods. All five compounds were evaluated for the cytotoxic effects on tsFT210 cell line by the SRB method.
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