Journal
NATURAL PRODUCT REPORTS
Volume 36, Issue 3, Pages 430-457Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8np00049b
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Pyridoxal 5'-phosphate(PLP) is a versatile organic cofactor used to catalyze diverse reactions on amino acid, oxoacid, and amine substrates. Here we review the reactions catalyzed by PLP-dependent enzymes, highlighting enzymes reported in the natural product biosynthetic literature. We describe enzymes that catalyze transaminations, Claisen-like condensations, and beta- and gamma-eliminations and substitutions, along with epimerizations, decarboxylations, and transaldolations. Finally, we describe a newly reported group of O-2-, PLP-dependent enzymes. Altogether, natural product biosynthesis showcases the incredible versatility of PLP-dependent transformations for building chemical complexity.
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