Journal
NATURAL PRODUCT REPORTS
Volume 31, Issue 8, Pages 1026-1042Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3np70128j
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Funding
- Office of Naval Research [N00014-09-1-012]
- Vanderbilt Institute of Chemical Biology
- D. Stanley and Ann T. Tarbell Endowment fund
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Oligosaccharide natural products target a wide spectrum of biological processes including disruption of cell wall biosynthesis, interference of bacterial translation, and inhibition of human a-amylase. Correspondingly, oligosaccharides possess the potential for development as treatments of such diverse diseases as bacterial infections and type II diabetes. Despite their potent and selective activities and potential clinical relevance, isolated bioactive secondary metabolic oligosaccharides are less prevalent than other classes of natural products and their biosynthesis has received comparatively less attention. This review highlights the unique modes of action and biosynthesis of four classes of bioactive oligosaccharides: the orthosomycins, moenomycins, saccharomicins, and acarviostatins.
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