Journal
NATURAL PRODUCT REPORTS
Volume 31, Issue 10, Pages 1474-1487Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4np00073k
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Funding
- National Institute of Health [1R56AI101141, 1DP1GM106413]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R56AI101141] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [DP1GM106413] Funding Source: NIH RePORTER
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This review provides a summary of recent research advances in elucidating the biosynthesis of fungal indole alkaloids. The different strategies used to incorporate and derivatize the indole/indoline moieties in various families of fungal indole alkaloids will be discussed, including tryptophan-containing nonribosomal peptides, polyketide-nonribosomal peptide hybrids, and alkaloids derived from other indole building blocks. This review also includes a discussion regarding the downstream modifications that generate chemical and structural diversity among indole alkaloids.
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