Journal
NATURAL PRODUCT REPORTS
Volume 31, Issue 7, Pages 870-879Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4np00003j
Keywords
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Funding
- Department of Science and Technology [SR/S1/OC-40/2009]
- Council of Scientific and Industrial Research [01(2376)/10/EMR-II]
- CSIR-New Delhi
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Bacteria have unusual glycans on their surfaces which distinguish them from the host cells. These unique structures offer avenues for targeting bacteria with specific therapeutics and vaccine. However, these rare sugars are not accessible in acceptable purity and amounts by isolation from natural sources. Thus, procurement of orthogonally protected rare sugar building blocks through efficient chemical synthesis is regarded as a crucial step towards the development of glycoconjugate vaccines. This Highlight focuses on recent advances in the synthesis of the bacterial deoxy amino hexopyranoside building blocks and their application in constructing various biologically important bacterial O-glycans.
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