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AMERICAN JOURNAL OF GASTROENTEROLOGY (2008)
Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin through mitochondrial death cascade
Chandan Mandal et al.
APOPTOSIS (2008)
Induction of apoptosis by withaferin A in human leukemia U937 cells through down-regulation of Akt phosphorylation
Jung Hwa Oh et al.
APOPTOSIS (2008)
Expression and function of the bile acid receptor TGR5 in Kupffer cells
Verena Keitel et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
Antiproliferative activity of derivatives of ouabain, digoxin and proscillaridin a in human MCF-7 and MDA-MB-231 breast cancer cells
Katarzyna Winnicka et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2008)
New lithocholic and chenodeoxycholic piperazinylcarboxamides with antiproliferative and pro-apoptotic effects on human cancer cell lines
Laila El Kihel et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2008)
Vitamin D Status and the Risk of Lung Cancer: A Cohort Study in Finland
Annamari Kilkkinen et al.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2008)
A chenodeoxycholic derivative, HS-1200, induces apoptosis and cell cycle modulation via Egr-1 gene expression control on human hepatoma cells
Sang Eun Park et al.
CANCER LETTERS (2008)
Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function
Reza Beheshti Zavareh et al.
CANCER RESEARCH (2008)
Cardenolides from Antiaris toxicaria as potent selective Nur77 modulators
Miao-Miao Jiang et al.
CHEMICAL & PHARMACEUTICAL BULLETIN (2008)
Mechanism-based inactivation of human cytochromes P450s: Experimental characterization, reactive intermediates, and clinical implications
Paul F. Hollenberg et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2008)
Structure-based design of a superagonist ligand for the vitamin D nuclear receptor
Shinji Hourai et al.
CHEMISTRY & BIOLOGY (2008)
A new cytotoxic bufadienolide from Chinese medicine Chansu
Xiu Lan Xin et al.
CHINESE CHEMICAL LETTERS (2008)
Antimetastatic effect of an orally active heparin derivative on experimentally induced metastasis
Dong Yun Lee et al.
CLINICAL CANCER RESEARCH (2008)
High-throughput screening identifies cardiac glycosides as potent inhibitors of human tissue kallikrein expression: Implications for cancer therapies
Ioannis Prassas et al.
CLINICAL CANCER RESEARCH (2008)
CYP17 inhibitors for prostate cancer treatment - An update
V. M. Moreira et al.
CURRENT MEDICINAL CHEMISTRY (2008)
Bisursodeoxycholate(ethylenediamine)platinum(II): a new autofluorescent compound. Cytotoxic activity and cell cycle analysis in ovarian and hematological cell lines
Martin Perez-Andres et al.
DALTON TRANSACTIONS (2008)
Plant-derived compounds in clinical trials
Arvind Saklani et al.
DRUG DISCOVERY TODAY (2008)
Role of vitamin D receptor in the lithocholic acid- mediated CYP3A induction in vitro and in vivo
Tsutomu Matsubara et al.
DRUG METABOLISM AND DISPOSITION (2008)
Dutasteride - A review of its use in the management of prostate disorders
Susan J. Keam et al.
DRUGS (2008)
Regulation of cholesterologenesis by the oxysterol receptor, LXRα
Yongjun Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Cholesterol, reactive oxygen species, and the formation of biologically active mediators
Robert C. Murphy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Circulating 25-hydroxyvitamin D levels and survival in patients with colorectal cancer
Kimmie Ng et al.
JOURNAL OF CLINICAL ONCOLOGY (2008)
Review of cytotoxic cephalostatins and ritterazines: Isolation and synthesis
Bryan R. Moser
JOURNAL OF NATURAL PRODUCTS (2008)
The cephalostatin way of apoptosis
Anita Rudy et al.
JOURNAL OF NATURAL PRODUCTS (2008)
Isolation, biological significance, synthesis, and cytotoxic evaluation of new natural parathiosteroids A-C and analogues from the soft coral Paragorgia sp.
Javier Jesus Poza et al.
JOURNAL OF ORGANIC CHEMISTRY (2008)
Discovering oxysterols in plasma:: A window on the metabolome
William J. Griffiths et al.
JOURNAL OF PROTEOME RESEARCH (2008)
Biochemical and computational insights into the anti-aromatase activity of natural catechol estrogens
Marco A. C. Neves et al.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2008)
In vivo and in vitro effect of novel 4,16-pregnadiene-6,20-dione derivatives, as 5α-reductase inhibitors
Eugene Bratoeff et al.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2008)
Novel Gemini vitamin D3 analogs have potent antitumor activity
Tsuyako Saito et al.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2008)
Calcium Plus Vitamin D Supplementation and the Risk of Breast Cancer
Rowan T. Chlebowski et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2008)
Vitamin D analogs: Therapeutic applications and mechanisms for selectivity
Alex J. Brown et al.
MOLECULAR ASPECTS OF MEDICINE (2008)
1α,25-Dihydroxyvitamin D3 potentiates cisplatin antitumor activity by p73 induction in a squamous cell carcinoma model
Yingyu Ma et al.
MOLECULAR CANCER THERAPEUTICS (2008)
Enantiospecific interactions between cholesterol and phospholipids
Juha-Matti Alakoskela et al.
LANGMUIR (2008)
Inhibitory effects of cholesterol derivatives on DNA polymerase and topoisomerase activities, and human cancer cell growth
Chisato Ishimaru et al.
LIPIDS (2008)
Targeting the alpha 1 subunit of the sodium pump to combat glioblastoma cells
Florence Lefranc et al.
NEUROSURGERY (2008)
DICKKOPF-4 is induced by TCF/β-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1α, 25-dihydroxyvitamin D3
N. Pendas-Franco et al.
ONCOGENE (2008)
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth
Huafeng Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Biological activity of novel progesterone derivatives having a bulky ester side chains at C-3
Marisa Cabeza et al.
STEROIDS (2008)
Neighboring group participation Part 17 Stereoselective synthesis of some steroidal 2-oxazolidones, as novel potential inhibitors of 17α-hydroxylase-C17,20-lyase
Dora Ondre et al.
STEROIDS (2008)
Synthesis of novel C17 steroidal carbamates Studies on CYP17 action, androgen receptor binding and function, and prostate cancer cell growth
Vania M. A. Moreira et al.
STEROIDS (2008)
Endocrine and paracrine role of bile acids
Verena Keitel et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2008)
Association between Fecal Bile Acids and Colorectal Cancer: A Meta-analysis of Observational Studies
Jin Lu Tong et al.
YONSEI MEDICAL JOURNAL (2008)
Combination therapy of heparin-deoxycholic acid conjugate and doxorubicin against squamous cell carcinoma and B16F10 melanoma
Kyeongsoon Park et al.
PHARMACEUTICAL RESEARCH (2008)
Serum 25-hydroxyvitamin D and risk of post-menopausal breast cancer - results of a large case-control study
Sascha Abbas et al.
CARCINOGENESIS (2008)
Identification of squalamine in the plasma membrane of white blood cells in the sea lamprey, Petromyzon marinus
Sang-Seon Yun et al.
JOURNAL OF LIPID RESEARCH (2007)
Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors
Vania M. A. Moreira et al.
STEROIDS (2007)
Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids
Bryson W. Katona et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Enantiomeric deoxycholic acid: Total synthesis, characterization, and preliminary toxicity toward colon cancer cell lines
Bryson W. Katona et al.
JOURNAL OF ORGANIC CHEMISTRY (2007)
Low-calcemic, highly antiproliferative, 23-oxa ether analogs of the natural hormone 1α,25-dihydroxyvitamin D3:: Design, synthesis, and preliminary biological evaluation
Kimberly S. Petersen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Prospective study of serum vitamin D and cancer mortality in the United States
D. Michal Freedman et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2007)
Cytotoxic cardenolide glycosides of Roupellina (Strophanthus) boivinii from the Madagascar rainforest
Sampada Karkare et al.
JOURNAL OF NATURAL PRODUCTS (2007)
Novel cytotoxic agents from an unexpected source: Bile acids and ovarian tumor apoptosis
Neil S. Horowitz et al.
GYNECOLOGIC ONCOLOGY (2007)
Deoxycholic acid-derived tetraoxane antimalarials and antiproliferatives
Natasa Terzic et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
A surface on the androgen receptor that allosterically regulates coactivator binding
Eva Estebanez-Perpina et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Bile acid transporters: Structure, function, regulation and pathophysiological implications
Waddah A. Alrefai et al.
PHARMACEUTICAL RESEARCH (2007)
3,17-disubstituted 2-Alkylestra-1,3,5(10)-trien-3-ol derivatives: Synthesis, in vitro and in vivo anticancer activity
Christian Bubert et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
SERMs for the treatment and prevention of breast cancer
Ramona F. Swaby et al.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS (2007)
Cardenolides from Saussurea stella with cytotoxicity toward cancer cells
Tian-Min Wang et al.
JOURNAL OF NATURAL PRODUCTS (2007)
Antiproliferative, low-calcemic, fluorinated sulfone analogs of 1α,25-dihydroxyvitamin D3:: Chemical synthesis and biological evaluation
Aimee R. Usera et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2007)
Exploitation of bile acid transport systems in prodrug design
Efna Sievanen
MOLECULES (2007)
Endogenous and exogenous cardiac glycosides: their roles in hypertension, salt metabolism, and cell growth
Wilhelm Schoner et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2007)
Digitoxin as an anticancer agent with selectivity for cancer cells:: possible mechanisms involved
Miguel Lopez-Lazaro
EXPERT OPINION ON THERAPEUTIC TARGETS (2007)
Synthesis and evaluation of new 6-hydroximinosteroid analogs as cytotoxic agents
Javier Poza et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2007)
Bioactive Cardenolides from the Stems and Twigs of Nerium oleander
Ming Zhao et al.
JOURNAL OF NATURAL PRODUCTS (2007)
Synthesis and cytotoxic activity of cisplatin analogue with an ursodeoxycholate ligand
Martin Perez-Andres et al.
LETTERS IN DRUG DESIGN & DISCOVERY (2007)
Calcitriol derivatives with two different side-chains at C-20. Part 4: Further chain modifications that alter VDR-dependent monocytic differentiation potency in human leukemia cells
Edward Garay et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2007)
The α1 subunit of the sodium pump could represent a novel target to combat non-small cell lung cancers
T. Mijatovic et al.
JOURNAL OF PATHOLOGY (2007)
UNBS1450: A new hemi-synthetic cardenolide with promising anti-cancer activity
Tatjana Mijatovic et al.
DRUG DEVELOPMENT RESEARCH (2007)
New cytotoxic steroids from the soft coral Clavularia viridis
Chang-Yih Duh et al.
STEROIDS (2007)
Androgens and androgen receptors in breast cancer
B. Nicolas Diaz-Chico et al.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2007)
Antiproliferative cardenolides of an Elaeodendron sp from the Madagascar rain Forest
Shugeng Cao et al.
JOURNAL OF NATURAL PRODUCTS (2007)
Methyl spongoate, a cytotoxic steroid from the Sanya soft coral Spongodes sp.
Xiao-Hong Yan et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Novel bile acid derivatives (BANBs) with cytostatic activity obtained by conjugation of their side chain with nitrogenated bases
Marta Vallejo et al.
BIOCHEMICAL PHARMACOLOGY (2007)
Synthesis of some steroidal oximes, lactams, thiolactams and their antitumor activities
Natalija M. Krstic et al.
STEROIDS (2007)
Calcitriol is a potent inhibitor of retinal neovascularization
Daniel M. Albert et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2007)
Suppression of angiogenesis and tumor growth by orally active deoxycholic acid-heparin conjugate
Dong Yun Lee et al.
JOURNAL OF CONTROLLED RELEASE (2007)
Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Oxysterols block transport by binding to Insig
Arun Radhakrishnan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins
Li-Ping Sun et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Ursodeoxycholic acid versus sulfasalazine in colitis-related colon carcinogenesis in mice
Hiroyuki Kohno et al.
CLINICAL CANCER RESEARCH (2007)
Antitumor properties of diastereomeric and geometric analoas of vitamin D3
Joanna Wietrzyk et al.
ANTI-CANCER DRUGS (2007)
Plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D and risk of incident ovarian cancer
Shelley S. Tworoger et al.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2007)
Docetaxel-induced growth inhibition and apoptosis in androgen independent prostate cancer cells are enhanced by 1α,25-dihydroxyvitamin D3
Huei-Ju Ting et al.
CANCER LETTERS (2007)
22-alkyl-20-epi-1α,25-dihydroxyvitamin D3 compounds of superagonistic activity:: Syntheses, biological activities and interaction with the receptor
Keiko Yamamoto et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Calcitriol derivatives with two different side chains at C-20III. An epimeric pair of the gemini family with unprecedented antiproliferative effects on tumor cells and renin mRNA expression inhibition
Hubert Maehr et al.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2007)
Evaluation of C-2-substituted 19-nor-1α,25-dihydroxyvitamin D3 analogs as therapeutic agents for prostate cancer
T. C. Chen et al.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2007)
A prospective study of plasma vitamin D metabolites, vitamin D receptor polymorphisms, and prostate cancer
Haojie Li et al.
PLOS MEDICINE (2007)
Optimal vitamin D status for colorectal cancer prevention - A quantitative meta analysis
Edward D. Gorham et al.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE (2007)
Synthesis and evaluation of isomeric (17α,20E)-11β-methoxy-21-(trifluoromethylphenyl)-19-norpregna-1,3,5(10),20-tetraene-3,17β-diols as ERα-Hormone binding domain ligands:: Effect of the methoxy group on receptor binding and uterotrophic growth
Robert N. Hanson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
The tumor proteasome is a primary target for the natural anticancer compound withaferin a isolated from Indian Winter Cherry
Huanjie Yang et al.
MOLECULAR PHARMACOLOGY (2007)
Apoptosis is induced in leishmanial cells by a novel protein kinase inhibitor withaferin A and is facilitated by apoptotic topoisomerase I-DNA complex
N. Sen et al.
CELL DEATH AND DIFFERENTIATION (2007)
被撤回的出版物: Cardiac glycoside induces cell death via FasL by activating calcineurin and NF-AT, but apoptosis initially proceeds through activation of caspases (Retracted article. See vol. 18, pg. 910, 2013)
Pongali B. Raghavendra et al.
APOPTOSIS (2007)
Lack of enantiomeric specificity in the effects of anesthetic steroids on lipid bilayers
Juha-Matti Alakoskela et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2007)
Deoxycholate induces mitochondrial oxidative stress and activates NF-kappa B through multiple mechanisms in HCT-116 colon epithelial cells
C. M. Payne et al.
CARCINOGENESIS (2007)
Oleandrin induces apoptosis in human, but not in murine cells: Dephosphorylation of Akt, expression of FasL, and alteration of membrane fluidity
Pongali B. Raghavendra et al.
MOLECULAR IMMUNOLOGY (2007)
Antiproliferative cardenolides from Periploca graeca
Daniela Spera et al.
PLANTA MEDICA (2007)
Design, synthesis, and antitumor activity of bile acid-polyamine-nucleoside conjugates
Dimao Wu et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Cardiotonic steroids on the road to anti-cancer therapy
Tajana Mijatovic et al.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2007)
Cytotoxic oxysterols induce caspase-independent myelin figure formation and caspase-dependent polar lipid accumulation
Anne Vejux et al.
HISTOCHEMISTRY AND CELL BIOLOGY (2007)
A new cytotoxic cholesterol sulfate from marine sponge Halichondria rugosa
Hong-Jun Zhang et al.
NATURAL PRODUCT RESEARCH (2007)
Cytotoxic cardenolides from Streptocaulon griffithii
Xiao-Hui Zhang et al.
CHEMISTRY & BIODIVERSITY (2007)
Antiangiogenic effect of bile acid acylated heparin derivative
Kyeongsoon Park et al.
PHARMACEUTICAL RESEARCH (2007)
2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: Synthesis, in vitro SAR, protein crystallography, and in vivo activity
Mathew P. Leese et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Structure-activity relationship for inhibition of 5α-reductase by triterpenoids isolated from Ganoderma lucidum
Jie Liu et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2006)
Cardioactive Steroid Poisoning: A Comparison of Plant- and Animal-Derived Compounds
Fermin Barrueto et al.
JOURNAL OF MEDICAL TOXICOLOGY (2006)
Kalanchosides A-C, new cytotoxic bufadienolides from the aerial parts of Kalanchoe gracilis
Pei-Lin Wu et al.
ORGANIC LETTERS (2006)
In vitro and in vivo antitumour effects of novel, orally active bile acid-conjugated platinum complexes on rat hepatoma
Cecilia Barbara et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2006)
Expression of the bile acid receptor FXR in Barrett's esophagus and enhancement of apoptosis by guggulsterone in vitro
Andrea De Gottardi et al.
MOLECULAR CANCER (2006)
CYP24, the enzyme that catabolizes the antiproliferative agent vitamin D, is increased in lung cancer
Robert A. Parise et al.
INTERNATIONAL JOURNAL OF CANCER (2006)
The farnesoid X receptor is expressed in breast cancer and regulates apoptosis and aromatase expression
Karen E. Swales et al.
CANCER RESEARCH (2006)
Cardenolide glycosides from Pergularia tomentosa and their proapoptotic activity in Kaposi's sarcoma cells
Arafa I. Hamed et al.
JOURNAL OF NATURAL PRODUCTS (2006)
Expression of transporters potentially involved in the targeting of cytostatic bile acid derivatives to colon cancer and polyps
Maria R. Ballestero et al.
BIOCHEMICAL PHARMACOLOGY (2006)
Phase 1 trial of Anvirzel™ in patients with refractory solid tumors
T Mekhail et al.
INVESTIGATIONAL NEW DRUGS (2006)
C19-Steroids as androgen receptor modulators:: Design, discovery, and structure-activity relationship of new steroidal androgen receptor antagonists
Padma Marwah et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2006)
1α, 25-dihydroxyvitamin D3 suppresses interleukin-8-mediated prostate cancer cell angiogenesis
Bo-Ying Bao et al.
CARCINOGENESIS (2006)
Stereoselective synthesis of some 17β-dihydrooxazinyl steroids, as novel presumed inhibitors of 17α-hydroxylase-C17,20-lyase
Janos Wolfling et al.
STEROIDS (2006)
19-Nor- and 18,20-epoxy-cardenolides from the leaves of Calotropis gigantea
Thitima Lhinhatrakool et al.
JOURNAL OF NATURAL PRODUCTS (2006)
Role of nongenomic activation of phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase 1/2 pathways in 1,25133-mediated apoptosis in squamous cell carcinoma cells
Yingyu Ma et al.
CANCER RESEARCH (2006)
Inhibition of DNA topoisomerases I and II, and growth inhibition of breast cancer MCF-7 cells by ouabain, digoxin and proscillaridin A
Krzysztof Bielawski et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2006)
Digitoxin, at concentrations commonly found in the plasma of cardiac patients, antagonizes etoposide and idarubicin activity in K562 leukemia cells
M López-Lázaro et al.
LEUKEMIA RESEARCH (2006)
Inhibition of tumor growth and progression of LNCaP prostate cancer cells in athymic mice by androgen and liver X receptor agonist
Chih-pin Chuu et al.
CANCER RESEARCH (2006)
Cardiac glycosides initiate Apo2L/TRAIL-induced apoptosis in non-small cell lung cancer cells by up-regulation of death receptors 4 and 5
S Frese et al.
CANCER RESEARCH (2006)
Synthesis and antitumor activity of cholest-4α-methyl-7-en-3β-ol derivatives
Lan He et al.
STEROIDS (2006)
Contemporary use of digoxin in the management of cardiovascular disorders
Mihai Gheorghiade et al.
CIRCULATION (2006)
Deoxycholic acid induces intracellular signaling through membrane perturbations
Samira Jean-Louis et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Coordinate regulation of hepatic bile acid oxidation and conjugation by nuclear receptors
Jocelyn Trottier et al.
MOLECULAR PHARMACEUTICS (2006)
Cardenolide-induced lysosomal membrane permeabilization demonstrates therapeutic benefits in experimental human non-small cell lung cancers
Tatjana Mijatovic et al.
NEOPLASIA (2006)
Prospective study of predictors of vitamin D status and cancer incidence and mortality in men
E Giovannucci et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2006)
Endocrine functions of bile acids
SM Houten et al.
EMBO JOURNAL (2006)
Cellular toxicity of oxycholesterols
T Wielkoszynski et al.
BIOESSAYS (2006)
Promise of vitamin D analogues in the treatment of hyperproliferative conditions
S Masuda et al.
MOLECULAR CANCER THERAPEUTICS (2006)
Structure and function of human 17β-hydroxysteroid dehydrogenases
P Lukacik et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2006)
Cortistatins A, B, C, and D, anti-angiogenic steroidal alkaloids, from the marine sponge Corticium simplex
S Aoki et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)
Phase I study of STX 64 (667 Coumate) in breast cancer patients: The first study of a steroid sulfatase inhibitor
SJ Stanway et al.
CLINICAL CANCER RESEARCH (2006)
Estrogen receptors and human disease
BJ Deroo et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
The cardenolide UNBS1450 is able to deactivate nuclear factor κB-mediated cytoprotective effects in human non-small cell lung cancer cells
T Mijatovic et al.
MOLECULAR CANCER THERAPEUTICS (2006)
The role of vitamin D in cancer prevention
CF Garland et al.
AMERICAN JOURNAL OF PUBLIC HEALTH (2006)
Expression of VDR and CYP24A1 mRNA in human tumors
MG Anderson et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2006)
5,6 : 8,9-Diepoxy and other cytotoxic sterols from the marine sponge Homaxinella sp.
TA Mansoor et al.
JOURNAL OF NATURAL PRODUCTS (2006)
Bile acids aided by acid suppression therapy may be associated with the development of esophageal cancers in westernized societies
DH Stamp
MEDICAL HYPOTHESES (2006)
Pure oestrogen antagonists for the treatment of advanced breast cancer
Anthony Howell
ENDOCRINE-RELATED CANCER (2006)
Discovery and clinical development of dutasteride, a potent dual 5 alpha-reductase inhibitor
Stephen V. Frye
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2006)
Estrogen receptors as therapeutic targets in breast cancer
Eric A. Ariazi et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2006)
Synthesis of ent-25-hydroxycholesterol
Emily J. Westover et al.
STEROIDS (2006)
Trends in the development of new drugs for treatment of benign prostatic hyperplasia
Katarzyna Kulig et al.
CURRENT MEDICINAL CHEMISTRY (2006)
Bile salt-induced apoptosis involves NADPH oxidase isoform activation
R Reinehr et al.
GASTROENTEROLOGY (2005)
Synthetic bile acid derivatives induce apoptosis through a c-Jun N-terminal kinase and NF-κB-dependent process in human cervical carcinoma cells
E Im et al.
CANCER LETTERS (2005)
Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients
M López-Ládzaro et al.
JOURNAL OF NATURAL PRODUCTS (2005)
The effect of ursodeoxycholic acid on glycochenodeoxycholic acid-induced apoptosis in rat hepatoctes
S Utanohara et al.
TOXICOLOGY (2005)
Dual roles for cholesterol in mammalian cells
F Xu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Structure-activity relationships of new A,D-ring modified steroids as aromatase inhibitors: Design, synthesis, and biological activity evaluation
MMDS Cepa et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Cytotoxic principles from the Formosan milkweed, Asclepias curassavica
MC Roy et al.
JOURNAL OF NATURAL PRODUCTS (2005)
Proapoptotic effect on normal and tumor intestinal cells of cytostatic drugs with enterohepatic organotropism
MJ Monte et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
The Vitamin D endocrine system of the gut -: Its possible role in colorectal cancer prevention
HS Cross et al.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2005)
Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization
JM Langenhan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Endogenous ouabain - Upregulation of steroidogenic genes in hypertensive hypothalamus but not adrenal
JR Murrell et al.
CIRCULATION (2005)
Plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D and risk of breast cancer
ER Bertone-Johnson et al.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2005)
Na+-Ca2+ exchange in the regulation of cardiac excitation-contraction coupling
H Reuter et al.
CARDIOVASCULAR RESEARCH (2005)
Synthesis and evaluation of (17α,20Z)-21-(4-substituted-phenyl)-19-norpregna-1,3,5(10),20-tetraene-3,17β-diols as ligands for the estrogen receptor α hormone binding domain:: Comparison with 20E-isomers
RN Hanson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Bile acid induces hydrophobicity-dependent membrane alterations
S Akare et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2005)
Molecular biology of the 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase gene family
J Simard et al.
ENDOCRINE REVIEWS (2005)
Structure-activity relationships of 2-, 4-, or 6-substituted estrogens as aromatase inhibitors
M Numazawa et al.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2005)
Phase III trial of ursodeoxycholic acid to prevent colorectal adenoma recurrence
DS Alberts et al.
JOURNAL OF THE NATIONAL CANCER INSTITUTE (2005)
Polyoxygenated steroids from the gorgonian Isis hippuris
CH Chao et al.
JOURNAL OF NATURAL PRODUCTS (2005)
Aromatase inhibitors in the treatment of breast cancer
RW Brueggemeier et al.
ENDOCRINE REVIEWS (2005)
Autocrine metabolism of vitamin D in normal and malignant breast tissue
K Townsend et al.
CLINICAL CANCER RESEARCH (2005)
Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: Synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model
VD Handratta et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Steroid sulfatase: Molecular biology, regulation, and inhibition
MJ Reed et al.
ENDOCRINE REVIEWS (2005)
Nonpolar and short side chain groups at C-11β of estradiol result in antiestrogens
JX Zhang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
New 5α-reductase inhibitors:: In vitro and in vivo effects
V Pérez-Ornelas et al.
STEROIDS (2005)
Cytotoxic sterol derivatives from a marine sponge Homaxinella sp.
TA Mansoor et al.
JOURNAL OF NATURAL PRODUCTS (2005)
Comparison of the cytotoxic, pro-oxidant and pro-inflammatory characteristics of different oxysterols
S Lemaire-Ewing et al.
CELL BIOLOGY AND TOXICOLOGY (2005)
Relevance and mechanism of oxysterol stereospecifity in coronary artery disease
A Rimner et al.
FREE RADICAL BIOLOGY AND MEDICINE (2005)
Identification of a novel cardenolide (2-oxovoruscharin) from Calotropis procera and the hemisynthesis of novel derivatives displaying potent in vitro antitumor activities and high in vivo tolerance:: Structure-activity relationship analyses
E Van Quaquebeke et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Oxidised Products of Cholesterol: Their Role in Apoptosis
Lisa Ryan et al.
CURRENT NUTRITION & FOOD SCIENCE (2005)
1α,25-Dihydroxyvitamin D3 is a preventive factor in the metastasis of lung cancer
K Nakagawa et al.
CARCINOGENESIS (2005)
Mitochondrial perturbation attenuates bile acid-induced cytotoxicity
CM Payne et al.
CELL BIOLOGY AND TOXICOLOGY (2005)
Ursodeoxycholic acid can suppress deoxycholic acid-induced apoptosis by stimulating Akt/PKB-dependent survival signaling
E Im et al.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2005)
Chemistry and structural biology of androgen receptor
WQ Gao et al.
CHEMICAL REVIEWS (2005)
Recent advances in the chemistry and pharmacological activity of new steroidal antiandrogens and 5 alpha-reductase inhibitors
E Bratoeff et al.
CURRENT MEDICINAL CHEMISTRY (2005)
Na/K-atpase, endogenous digitalis-like compounds and cancer development - A hypothesis
H Weidemann
FRONTIERS IN BIOSCIENCE-LANDMARK (2005)
Vitamin D and cancer: An update of in vitro and in vivo data
P Ordonez-Moran et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2005)
Ouabain assembles signaling cascades through the caveolar Na+/K+-ATPase
HJ Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Up-regulation of Na+K+-ATPase α3-isoform and down-regulation of the α1-isoform in human colorectal cancer
H Sakai et al.
FEBS LETTERS (2004)
Cytotoxic sterols and saponins from the starfish Certonardoa semiregularis
WH Wang et al.
JOURNAL OF NATURAL PRODUCTS (2004)
New polyoxygenated steroids from the Antarctic octocoral Dasystenella acanthina
GG Mellado et al.
STEROIDS (2004)
Phorbasterones A-D, cytotoxic Nor-ring a steroids from the sponge Phorbas amaranthus
MN Masuno et al.
JOURNAL OF NATURAL PRODUCTS (2004)
Oxysterols regulate expression of the steroidogenic acute regulatory protein
SR King et al.
JOURNAL OF MOLECULAR ENDOCRINOLOGY (2004)
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion markers in CD-1 mouse skin by oleandrin
F Afaq et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2004)
New steroidal dimers with antifungal and antiproliferative activity
DB Salunke et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
New cytotoxic steroids from the Indian ocean sponge Axinella cf. bidderi
C Funel et al.
JOURNAL OF NATURAL PRODUCTS (2004)
Characterization of new estrogen receptor destabilizing compounds:: Effects on estrogen-sensitive and tamoxifen-resistant breast cancer
J Hoffmann et al.
JOURNAL OF THE NATIONAL CANCER INSTITUTE (2004)
Clinical significance of the overexpression of the candidate oncogene CYP24 in esophageal cancer
K Mimori et al.
ANNALS OF ONCOLOGY (2004)
Cytotoxic cardenolide glycoside from the seeds of Cerbera odollam
S Laphookhieo et al.
PHYTOCHEMISTRY (2004)
New nardosinanes and 19-oxygenated ergosterols from the soft coral Nephthea armata collected in Taiwan
AAH El-Gamal et al.
JOURNAL OF NATURAL PRODUCTS (2004)
Antiapoptotic effect of ouabain on human umbilical vein endothelial cells
L Trevisi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
New cytotoxic cardenolide glycoside from the seeds of Cerbera manghas
S Cheenpracha et al.
CHEMICAL & PHARMACEUTICAL BULLETIN (2004)
Neighboring group participation -: Part 15.: Stereoselective synthesis of some steroidal tetrahydrooxazin-2-ones, as novel presumed inhibitors of human 5α-reductase
J Wölfting et al.
STEROIDS (2004)
Steroidal Saponins from Myriopteron extensum and their cytotoxic activity
MF Yang et al.
PLANTA MEDICA (2004)
Antiproliferative effect of liver X receptor agonists on LNCaP human prostate cancer cells
J Fukuchi et al.
CANCER RESEARCH (2004)
Mitochondrially-mediated toxicity of bile acids
CM Palmeira et al.
TOXICOLOGY (2004)
Cholesterol is essential for mitosis progression and its deficiency induces polyploid cell formation
C Fernández et al.
EXPERIMENTAL CELL RESEARCH (2004)
Estrone formate: a novel type of irreversible inhibitor of human steroid sulfatase
EP Schreiner et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
Additional cytotoxic sterols and saponins from the starfish Certonardoa semiregularis
WH Wang et al.
JOURNAL OF NATURAL PRODUCTS (2004)
Anti-tumor activity of calcitriol: pre-clinical and clinical studies
DL Trump et al.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2004)
Role of mitochondrial dysfunction in combined bile acid-induced cytotoxicity: The switch between apoptosis and necrosis
AP Rolo et al.
TOXICOLOGICAL SCIENCES (2004)
Cholesterol depletion results in site-specific increases in epidermal growth factor receptor phosphorylation due to membrane level effects - Studies with cholesterol enantiomers
EJ Westover et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Apoptosis-mediated selective killing of malignant cells by cardiac steroids:: maintenance of cytotoxicity and loss of cardiac activity of chemically modified derivatives
D Daniel et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2003)
Organic chemistry of vitamin D analogues (deltanoids)
GH Posner et al.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2003)
Antiproliferative activity of cardenolides isolated from streptocaulon juventas
JY Ueda et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2003)
Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor
H Fang et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2003)
Aplidiasterols A and B, two new cytotoxic 9,11-secosterols from the mediterranean ascidian Aplidium conicum
A Aiello et al.
STEROIDS (2003)
Apoptosis and modulation of cell cycle control by synthetic derivatives of ursodeoxycholic acid and chenodeoxycholic acid in human prostate cancer cells
YH Choi et al.
CANCER LETTERS (2003)
Breast cancer tissue estrogens and their manipulation with aromatase inhibitors and inactivators
H Geisler
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2003)
Iα,25-dihydroxyvitamin D3 (calcitriol) and its analogue, 19-nor-Iα,25(OH)2D2, potentiate the effects of ionising radiation on human prostate cancer cells
N Dunlap et al.
BRITISH JOURNAL OF CANCER (2003)
Synthesis and evaluation of 17α-20E-21-(4-substituted phenyl)-19-norpregna-1,3,5(10),20-tetraene-3,17β-diols as probes for the estrogen receptor α hormone binding domain
RN Hanson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Antimalarial and antiproliferative evaluation of bis-steroidal tetraoxanes
R Opsenica et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2003)
Drug therapy: Aromatase inhibitors in breast cancer
IE Smith et al.
NEW ENGLAND JOURNAL OF MEDICINE (2003)
Synthesis and evaluation of B-, C-, and D-ring-substituted estradiol carboxylic acid esters as locally active estrogens
DC Labaree et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Toxicity of cholesterol oxidation products to Caco-2 and HepG2 cells:: Modulatory effects of α- and γ-tocopherol
AJ O'Sullivan et al.
JOURNAL OF APPLIED TOXICOLOGY (2003)
D-ring modified estrone derivatives as novel potent inhibitors of steroid sulfatase
DS Fischer et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2003)
Oxidized cholesterol in the diet is a source of oxidized lipoproteins in human serum
I Staprans et al.
JOURNAL OF LIPID RESEARCH (2003)
Cholic acid-carboplatin compounds (CarboChAPt) as models for specific drug delivery: synthesis of novel carboplatin analogous derivatives and comparison of the cytotoxic properties with corresponding cisplatin compounds
R Paschke et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2003)
1α,3β,5β-Trihydroxy-24-methylenecholestan-6-one:: a novel steroid from a soft coral Sinularia gibberosa
AF Ahmed et al.
STEROIDS (2003)
A G protein-coupled receptor responsive to bile acids
Y Kawamata et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Bioactive sterols from the starfish Certonardoa semiregularis
WH Wang et al.
JOURNAL OF NATURAL PRODUCTS (2003)
Synthetic chenodeoxycholic acid derivative HS-1200-induced apoptosis of p815 mastocytoma cells is augmented by co-treatment with lactacystin
SY Seo et al.
ANTI-CANCER DRUGS (2003)
Effect of a novel steroid (PM-9) on the inhibition of 5α-reductase present in Penicillium crustosum broths
E Flores et al.
STEROIDS (2003)
Usefulness of liposomes loaded with cytostatic bile acid derivatives to circumvent chemotherapy resistance of enterohepatic tumors
O Briz et al.
MOLECULAR PHARMACOLOGY (2003)
Synthesis of 21,21-difluoro-3β-hydroxy-20-methylpregna-5,20-diene and 5,16,20-triene as potential inhibitors of steroid C17(20) lyase
PM Weintraub et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2003)
Bufadienolide and spirostanol glycosides from the rhizomes of Helleborus orientalis
K Watanabe et al.
JOURNAL OF NATURAL PRODUCTS (2003)
Effects of natural and enantiomeric cholesterol on the thermotropic phase behavior and structure of egg sphingomyelin bilayer membranes
DA Mannock et al.
BIOPHYSICAL JOURNAL (2003)
Evaluation of 17α-E-(trifluoromethylphenyl)vinyl estradiols as novel estrogen receptor ligands
RN Hanson et al.
STEROIDS (2003)
Novel D-ring modified steroid derivatives as potent, non-estrogenic, steroid sulfatase inhibitors with in vivo activity
DS Fischer et al.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2003)
Mitochondrially mediated synergistic cell killing by bile acids
AP Rolo et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2003)
New cytotoxic steroidal alkaloids from the Philippine sponge Corticium niger
CP Ridley et al.
JOURNAL OF NATURAL PRODUCTS (2003)
Constituents of the Vietnamese medicinal plant Streptocaulon juventas and their antiproliferative activity against the human HT-1080 fibrosarcoma cell line
J Ueda et al.
JOURNAL OF NATURAL PRODUCTS (2003)
Steroid 5 alpha-Reductase Inhibitors
Eugenio Flores et al.
MINI-REVIEWS IN MEDICINAL CHEMISTRY (2003)
QSAR evaluation of the Ch'an Su and related bufadienolides against the colchicine-resistant primary liver carcinoma cell line PLC/PRF/51
Y Kamano et al.
JOURNAL OF MEDICINAL CHEMISTRY (2002)
Long-term (7 to 8-year) experience with finasteride in men with benign prostatic hyperplasia
D Vaughan et al.
UROLOGY (2002)
Oxidized products of cholesterol: dietary and metabolic origin, and proatherosclerotic effects (review)
G Leonarduzzi et al.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2002)
Enhancement of radiotherapy by oleandrin is a caspase-3 dependent process
S Nasu et al.
CANCER LETTERS (2002)
Identification of membrane-type receptor for bile acids (M-BAR)
T Maruyama et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
New cytotoxic constituents from the Formosan soft corals Clavularia viridis and Clavularia violacea
CY Duh et al.
JOURNAL OF NATURAL PRODUCTS (2002)
Bile acids stimulate invasion and haptotaxis in human colorectal cancer cells through activation of multiple oncogenic signaling pathways
PR Debruyne et al.
ONCOGENE (2002)
The role of fibroblast growth factors in vascular development
S Javerzat et al.
TRENDS IN MOLECULAR MEDICINE (2002)
New biologically active marine sesquiterpenoid and steroid from the Okinawan sponge of the genus Axinyssa
M Iwashima et al.
CHEMICAL & PHARMACEUTICAL BULLETIN (2002)
Bile salts, intestinal microflora and enterohepatic circulation
MH Floch
DIGESTIVE AND LIVER DISEASE (2002)
Plasma deoxycholic acid concentration is elevated in postmenopausal women with newly diagnosed breast cancer
V Costarelli et al.
EUROPEAN JOURNAL OF CLINICAL NUTRITION (2002)
Double-blind, Randomized trial comparing the efficacy and tolerability of fulvestrant versus anastrozole in postmenopausal women with advanced breast cancer progressing on prior endocrine therapy: Results of a North American trial
CK Osborne et al.
JOURNAL OF CLINICAL ONCOLOGY (2002)
Fulvestrant, formerly ICI 182,780, is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatment
A Howell et al.
JOURNAL OF CLINICAL ONCOLOGY (2002)
New polyoxygenated steroids exhibiting reversal of multidrug resistance from the gorgonian Isis hippuris
J Tanaka et al.
TETRAHEDRON (2002)
Minor steroidal alkaloids from the marine sponge Corticium sp.
N Borbone et al.
JOURNAL OF NATURAL PRODUCTS (2002)
Novel cytotoxic oxygenated C29 sterols from the Colombian marine sponge Polymastia tenax
G Santafe et al.
JOURNAL OF NATURAL PRODUCTS (2002)
Calcitriol (1,25-dihydroxycholecalciferol) potentiates activity of mitoxantrone/dexamethasone in an androgen independent prostate cancer model
S Ahmed et al.
JOURNAL OF UROLOGY (2002)
Characteristics of 7β-hydroxycholesterol-induced cell death in a human monocytic blood cell line, U937, and a human hepatoma cell line, HepG2
YC O'Callaghan et al.
TOXICOLOGY IN VITRO (2002)
Vitamin D receptor as an intestinal bile acid sensor
M Makishima et al.
SCIENCE (2002)
Na+/K+-ATPase as a signal transducer
ZJ Xie et al.
EUROPEAN JOURNAL OF BIOCHEMISTRY (2002)
Novel steroidal vinyl fluorides as inhibitors of steroid C17(20) lyase
JP Burkhart et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2002)
Carriers involved in targeting the cytostatic bile acid-cisplatin derivatives cis-diammine-chloro-cholylglycinate-platinum(II) and cis-diammine-bisursodeoxycholate-platinum(II) toward liver cells
O Briz et al.
MOLECULAR PHARMACOLOGY (2002)
Synthetic bile acids: Novel mediators of apoptosis
ND Kim et al.
JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY (2002)
Comparative cytotoxic and cytoprotective effects of taurohyodeoxycholic acid (THDCA) and tauroursodeoxycholic acid (TUDCA) in HepG2 cell line
F Carubbi et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2002)
Structure and cytotoxicity of new polyhydroxylated sterols from the Caribbean gorgonian Plexaurella grisea
A Rueda et al.
STEROIDS (2001)
Thrombospondin-1, vascular endothelial growth factor and fibroblast growth factor-2 are key functional regulators of angiogenesis in the prostate
JA Doll et al.
PROSTATE (2001)
Role of hydrophilic interaction in binding of hydroxylated 3-deoxy C19 steroids to the active site of aromatase
M Numazawa et al.
JOURNAL OF MEDICINAL CHEMISTRY (2001)
New steroidal alkaloids from an undescribed sponge of the genus Corticium
HS Lee et al.
JOURNAL OF NATURAL PRODUCTS (2001)
Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch'an Su
T Nogawa et al.
JOURNAL OF NATURAL PRODUCTS (2001)
The role of bile acids in carcinogenesis
PR Debruyne et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2001)
Inhibition of export of fibroblast growth factor-2 (FGF-2) from the prostate cancer cell lines PC3 and DU145 by Anvirzel and its cardiac glycoside component, oleandrin
JA Smith et al.
BIOCHEMICAL PHARMACOLOGY (2001)
Synthesis of cytotoxic 6E-hydroximino-4-ene steroids:: Structure/activity studies
N Deive et al.
JOURNAL OF MEDICINAL CHEMISTRY (2001)
Reversing effect of agosterol A, a spongean sterol acetate, on multidrug resistance in human carcinoma cells
S Aoki et al.
JAPANESE JOURNAL OF CANCER RESEARCH (2001)
Vitamin D3-induced apoptosis of murine squamous cell carcinoma cells -: Selective induction of caspase-dependent MEK cleavage and up-regulation of MEKK-1
TF McGuire et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Reflections on sterol sidechain cleavage process catalyzed by cytochrome P450scc
S Lieberman et al.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2001)
Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cells
S Johansson et al.
ANTI-CANCER DRUGS (2001)
Estradiol-16α-carboxylic acid esters as locally active estrogens
DC Labaree et al.
JOURNAL OF MEDICINAL CHEMISTRY (2001)
New cytotoxic steroids from the gorgonian Isis hippuris.: Structure-activity studies
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TETRAHEDRON (2001)
Role of oxidant stress in the permeability transition induced in rat hepatic mitochondria by hydrophobic bile acids
RJ Sokol et al.
PEDIATRIC RESEARCH (2001)
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
JL Staudinger et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Reversal of multidrug resistance and increase in plasma membrane fluidity in CHO cells with R-verapamil and bile salts
H Schuldes et al.
EUROPEAN JOURNAL OF CANCER (2001)
Novel bile acid derivatives induce apoptosis via a p53-independent pathway in human breast carcinoma cells
EO Im et al.
CANCER LETTERS (2001)
Comparative study of the cytotoxicity and apoptosis-inducing potential of commonly occurring oxysterols
YC O'Callaghan et al.
CELL BIOLOGY AND TOXICOLOGY (2001)
Probing the binding pocket of the active site of aromatase with 6-ether or 6-ester substituted androst-4-ene-3,17-diones and their diene and triene analogs
M Numazawa et al.
STEROIDS (2000)
Synthesis and evaluation of 4-deacetoxyagosterol A as an MDR-modulator
N Murakami et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2000)
Structure-activity relationships of 17α-derivatives of estradiol as inhibitors of steroid sulfatase
RP Boivin et al.
JOURNAL OF MEDICINAL CHEMISTRY (2000)
Synthesis and evaluation of novel steroidal oxime inhibitors of P450 17 (17α-hydroxylase/C17-20-lyase) and 5α-reductase types 1 and 2
RW Hartmann et al.
JOURNAL OF MEDICINAL CHEMISTRY (2000)
Mammalian bufadienolide is synthesized from cholesterol in the adrenal cortex by a pathway that is independent of cholesterol side-chain cleavage
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Evaluation of hydrophobic/hydrophilic balance of bile acids by comparative molecular field analysis (CoMFA)
G Costantino et al.
STEROIDS (2000)
LC/MS/MS analyses of an oleander extract for cancer treatment
XM Wang et al.
ANALYTICAL CHEMISTRY (2000)
Characterization of a novel analogue of 1α,25(OH)2-vitamin D3 with two side chains:: Interaction with its nuclear receptor and cellular actions
AW Norman et al.
JOURNAL OF MEDICINAL CHEMISTRY (2000)
Anvinel™, an extract of Nerium oleander, induces cell death in human but not murine cancer cells
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ANTI-CANCER DRUGS (2000)
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CANCER AND METASTASIS REVIEWS (2000)
Etoposide stimulates 1,25-dihydroxyvitamin D3 differentiation activity, hormone binding and hormone receptor expression in HL-60 human promyelocytic cells
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MOLECULAR AND CELLULAR BIOCHEMISTRY (2000)
Biological activity in vitro of side-chain modified analogues of calcitriol
A Opolski et al.
CURRENT PHARMACEUTICAL DESIGN (2000)
Glutathione status of isolated rat hepatocytes affects bile acid-induced cellular necrosis but not apoptosis
E Gumpricht et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2000)
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SM Singh et al.
CURRENT MEDICINAL CHEMISTRY (2000)
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