Journal
NATURAL PRODUCT REPORTS
Volume 28, Issue 7, Pages 1229-1260Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0np00013b
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Funding
- NIGMS NIH HHS [R37 GM052964, R01 GM052964] Funding Source: Medline
- PHS HHS [R37052964] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM052964, R37GM052964] Funding Source: NIH RePORTER
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The pyrrole-2-aminoimidazole (P-2-AI) alkaloids are a growing family of marine alkaloids, now numbering well over 150 members, with high topographical and biological information content. Their intriguing structural complexity, rich and compact stereochemical content, high N to C ratio (similar to 1 : 2), and increasingly studied biological activities are attracting a growing number of researchers from numerous disciplines world-wide. This review surveys advances in this area with a focus on the structural diversity, biosynthetic hypotheses with increasing, but still rare, verifying experimental studies, asymmetric syntheses, and biological studies, including cellular target receptor isolation studies, of this stimulating and exciting alkaloid family.
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