Journal
NATURAL PRODUCT REPORTS
Volume 28, Issue 3, Pages 511-528Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0np00001a
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Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM065503] Funding Source: NIH RePORTER
- NIGMS NIH HHS [GM065503] Funding Source: Medline
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Marine sponges belonging to the Calcarea family have been studied for some time and have yielded a wide variety of structurally unique secondary metabolites. In particular, these sponges have produced a large number of bioactive alkaloids containing an imidazole heterocycle, typically substituted with two benzylic fragments at various locations around the azole nucleus and at various oxidation states. This review will describe the isolation, structural determination and synthetic studies towards this growing class of natural products.
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