Journal
NATURAL PRODUCT REPORTS
Volume 28, Issue 11, Pages 1811-1853Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1np00045d
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Glyco(randomization/diversification) is a term that encompasses strategies to diversify a core drug scaffold via enzymatic glycosylation to provide sets of analogs wherein the sole diversity element is a carbohydrate. This review covers the influence of glycosylation upon various drug properties, the classes of glycosyl-conjugating enzymes amenable to glyco(randomization/diversification) schemes, approaches to the synthesis of required substrates and specific examples of glycorandomized libraries utilizing both wild-type and engineered enzymes.
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