Related references
Note: Only part of the references are listed.Insights into the Evolution of Macrolactam Biosynthesis through Cloning and Comparative Analysis of the Biosynthetic Gene Cluster for a Novel Macrocyclic Lactam, ML-449
Hanne Jorgensen et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2010)
Isolation and Characterization of the Gene Cluster for Biosynthesis of the Thiopeptide Antibiotic TP-1161
Kerstin Engelhardt et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2010)
Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation
Yihua Chen et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2010)
Biotechnological doxorubicin production: pathway and regulation engineering of strains for enhanced production
Narayan Prasad Niraula et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2010)
High-throughput DNA sequencing - concepts and limitations
Martin Kircher et al.
BIOESSAYS (2010)
Identification of the Tirandamycin Biosynthetic Gene Cluster from Streptomyces sp 307-9
Jacob C. Carlson et al.
CHEMBIOCHEM (2010)
Analysis of the Sorangicin Gene Cluster Reinforces the Utility of a Combined Phylogenetic/Retrobiosynthetic Analysis for Deciphering Natural Product Assembly by trans-AT PKS
Herbert Irschik et al.
CHEMBIOCHEM (2010)
Polyketide β-Branching in Bryostatin Biosynthesis: Identification of Surrogate Acetyl-ACP Donors for BryR, an HMG-ACP Synthase
Tonia J. Buchholz et al.
CHEMISTRY & BIOLOGY (2010)
Engineering of regulatory cascades and networks controlling antibiotic biosynthesis in Streptomyces
Juan-Francisco Martin et al.
CURRENT OPINION IN MICROBIOLOGY (2010)
Characterization of 5-Chloro-5-Deoxy-D-Ribose 1-Dehydrogenase in Chloroethylmalonyl Coenzyme A Biosynthesis SUBSTRATE AND REACTION PROFILING
Andrew J. Kale et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Engineering Fluorometabolite Production: Fluorinase Expression in Salinispora tropica Yields Fluorosalinosporamide
Alessandra S. Eustaquio et al.
JOURNAL OF NATURAL PRODUCTS (2010)
Functional Characterization of the Cyclomarin/Cyclomarazine Prenyltransferase CymD Directs the Biosynthesis of Unnatural Cyclic Peptides
Andrew W. Schultz et al.
JOURNAL OF NATURAL PRODUCTS (2010)
Shared Biosynthesis of the Saliniketals and Rifamycins in Salinispora arenicola is Controlled by the sare1259-Encoded Cytochrome P450
Micheal C. Wilson et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Complexity and simplicity in the biosynthesis of enediyne natural products
Zhao-Xun Liang
NATURAL PRODUCT REPORTS (2010)
Cyclization of aromatic polyketides from bacteria and fungi
Hui Zhou et al.
NATURAL PRODUCT REPORTS (2010)
Marine natural products
John W. Blunt et al.
NATURAL PRODUCT REPORTS (2010)
Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis
Carlos Olano et al.
NATURAL PRODUCT REPORTS (2010)
Biosynthesis of polyketides by trans-AT polyketide synthases
Joern Piel
NATURAL PRODUCT REPORTS (2010)
PKS and NRPS release mechanisms
Liangcheng Du et al.
NATURAL PRODUCT REPORTS (2010)
The unique mechanistic transformations involved in the biosynthesis of modular natural products from marine cyanobacteria
Adam C. Jones et al.
NATURAL PRODUCT REPORTS (2010)
Computational solutions to large-scale data management and analysis
Eric E. Schadt et al.
NATURE REVIEWS GENETICS (2010)
Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism
Mamoru Komatsua et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Conformational switch triggered by α-ketoglutarate in a halogenase of curacin A biosynthesis
Dheeraj Khare et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
The odyssey of marine pharmaceuticals: a current pipeline perspective
Alejandro M. S. Mayer et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2010)
Structural Perspective on Enzymatic Halogenation
Leah C. Blasiak et al.
ACCOUNTS OF CHEMICAL RESEARCH (2009)
The Biosynthetic Logic of Polyketide Diversity
Christian Hertweck
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)
Biosynthesis of Macrolactam BE-14106 Involves Two Distinct PKS Systems and Amino Acid Processing Enzymes for Generation of the Aminoacyl Starter Unit
Hanne Jorgensen et al.
CHEMISTRY & BIOLOGY (2009)
Recent advances in siderophore biosynthesis
Sarah M. Barry et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2009)
Chasing the treasures of the sea - bacterial marine natural products
Tobias A. M. Gulder et al.
CURRENT OPINION IN MICROBIOLOGY (2009)
Genomic islands link secondary metabolism to functional adaptation in marine Actinobacteria
Kevin Penn et al.
ISME JOURNAL (2009)
Exploring the Chemistry and Biology of Vanadium-dependent Haloperoxidases
Jaclyn M. Winter et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Function-Oriented Biosynthesis of β-Lactone Proteasome Inhibitors in Salinispora tropica
Markus Nett et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
In Vitro Biosynthesis of Unnatural Enterocin and Wailupemycin Polyketides
John A. Kalaitzis et al.
JOURNAL OF NATURAL PRODUCTS (2009)
Pederin-Type Pathways of Uncultivated Bacterial Symbionts: Analysis of O-Methyltransferases and Generation of a Biosynthetic Hybrid
Katrin Zimmermann et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Biosynthesis of Salinosporamides from α,β-Unsaturated Fatty Acids: Implications for Extending Polyketide Synthase Diversity
Yuan Liu et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Heterologous expression systems for polyketide synthases
Isao Fujii
NATURAL PRODUCT REPORTS (2009)
Mining cyanobacterial genomes for genes encoding complex biosynthetic pathways
John A. Kalaitzis et al.
NATURAL PRODUCT REPORTS (2009)
Genomic basis for natural product biosynthetic diversity in the actinomycetes
Markus Nett et al.
NATURAL PRODUCT REPORTS (2009)
Ribosomal peptide natural products: bridging the ribosomal and nonribosomal worlds
John A. McIntosh et al.
NATURAL PRODUCT REPORTS (2009)
New natural product biosynthetic chemistry discovered by genome mining
Christophe Corre et al.
NATURAL PRODUCT REPORTS (2009)
Metabolites from symbiotic bacteria
Joern Piel
NATURAL PRODUCT REPORTS (2009)
Structural insights into nonribosomal peptide enzymatic assembly lines
Alexander Koglin et al.
NATURAL PRODUCT REPORTS (2009)
Biosynthesis of polyketide synthase extender units
Yolande A. Chan et al.
NATURAL PRODUCT REPORTS (2009)
Metamorphic enzyme assembly in polyketide diversification
Liangcai Gu et al.
NATURE (2009)
Mechanistic considerations of halogenating enzymes
Alison Butler et al.
NATURE (2009)
Polyketide assembly lines of uncultivated sponge symbionts from structure-based gene targeting
Katja M. Fisch et al.
NATURE CHEMICAL BIOLOGY (2009)
Drug development from marine natural products
Tadeusz F. Molinski et al.
NATURE REVIEWS DRUG DISCOVERY (2009)
Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine
Alessandra S. Eustaquio et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome
Alessandra S. Eustaquio et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2008)
The fluorinase, the chlorinase and the duf-62 enzymes
Hai Deng et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2008)
Genome mining for novel natural product discovery
Gregory L. Challis
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Engineered biosynthesis of antiprotealide and other unnatural salinosporamide proteasome inhibitors
Ryan P. McGlinchey et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
Unraveling the biosynthesis of the sporolide cyclohexenone building block
Ryan P. McGlinchey et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
Biosynthesis and structures of cyclomarins and cyclomarazines, prenylated cyclic peptides of marine actinobacterial origin
Andrew W. Schultz et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
Isoprenoid-like alkylations in polyketide biosynthesis
Christopher T. Calderone
NATURAL PRODUCT REPORTS (2008)
Trading molecules and tracking targets in symbiotic interactions
Eric W. Schmidt
NATURE CHEMICAL BIOLOGY (2008)
Discovery and characterization of a marine bacterial SAM-dependent chlorinase
Alessandra S. Eustaquio et al.
NATURE CHEMICAL BIOLOGY (2008)
Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula -: Insights into a decarboxylase involved in polyketide chain β-branching
Todd W. Geders et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Cloning and biochemical characterization of the hectochlorin biosynthetic gene cluster from the marine cyanobacterium Lyngbya majuscula
Aishwarya V. Ramaswamy et al.
JOURNAL OF NATURAL PRODUCTS (2007)
GNAT-like strategy for polyketide chain initiation
Liangcai Gu et al.
SCIENCE (2007)
Enzymatic total synthesis of enterocin polyketides
Qian Cheng et al.
NATURE CHEMICAL BIOLOGY (2007)
Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica
Daniel W. Udwary et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Species-specific secondary metabolite production in marine actinomycetes of the genus Salinispora
Paul R. Jensen et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2007)
The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis
Rebecca A. Butcher et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Identification of the putative bryostatin polyketide synthase gene cluster from Candidatus endobugula sertula, the uncultivated microbial symbiont of the marine bryozoan Bugula neritina
Sebastian Sudek et al.
JOURNAL OF NATURAL PRODUCTS (2007)
Molecular basis for chloronium-mediated meroterpene cyclization - Cloning, sequencing, and heterologous expression of the napyradiomycin biosynthetic gene cluster
Jaclyn M. Winter et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Systems biology of antibiotic production by microorganisms
J. Stefan Rokem et al.
NATURAL PRODUCT REPORTS (2007)
Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork
Christian Hertweck et al.
NATURAL PRODUCT REPORTS (2007)
Natural combinatorial peptide libraries in cyanobacterial symbionts of marine ascidians
Mohamed S. Donia et al.
NATURE CHEMICAL BIOLOGY (2006)
Structural biology and chemistry of the terpenoid cyclases
David W. Christianson
CHEMICAL REVIEWS (2006)
Nature's inventory of halogenation catalysts: Oxidative strategies predominate
Frederic H. Vaillancourt et al.
CHEMICAL REVIEWS (2006)
Characterization of the initial enzymatic steps of barbamide biosynthesis
Patricia M. Flatt et al.
JOURNAL OF NATURAL PRODUCTS (2006)
Convergence of isoprene and polyketide biosynthetic machinery:: Isoprenyl-S-carrier proteins in the pksX pathway of Bacillus subtilis
Christopher T. Calderone et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Structure of trichamide, a cyclic peptide from the bloom-forming cyanobacterium Trichodesmium erythraeum, predicted from the genome sequence
Sebastian Sudek et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2006)
Halogenation of unactivated carbon centers in natural product biosynthesis: Trichlorination of leucine during barbamide biosynthesis
DP Galonic et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)
Crystal structure of the non-haem iron halogenase SyrB2 in syringomycin biosynthesis
LC Blasiak et al.
NATURE (2006)
Biosynthesis of marine natural products: macroorganisms (Part B)
Bradley S. Moore
NATURAL PRODUCT REPORTS (2006)
The biosynthesis, molecular genetics and enzymology of the polyketide-derived metabolites
AM Hill
NATURAL PRODUCT REPORTS (2006)
Privileged structures as leads in medicinal chemistry
L Costantino et al.
CURRENT MEDICINAL CHEMISTRY (2006)
Shotgun cloning and heterologous expression of the patellamide gene cluster as a strategy to achieving sustained metabolite production
PF Long et al.
CHEMBIOCHEM (2005)
From chemical structure to environmental biosynthetic pathways: navigating marine invertebrate-bacteria associations
EW Schmidt
TRENDS IN BIOTECHNOLOGY (2005)
Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis
FH Vaillancourt et al.
NATURE (2005)
SyrB2 in syringomycin E biosynthesis is a nonherne FeII α-ketoglutarate- and O2-dependent halogenase
FH Vaillancourt et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Biochemical characterization of a prokaryotic phenylalanine ammonia lyase
LK Xiang et al.
JOURNAL OF BACTERIOLOGY (2005)
Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella
EW Schmidt et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Molecular mechanisms underlying nonribosomal peptide synthesis: Approaches to new antibiotics
SA Sieber et al.
CHEMICAL REVIEWS (2005)
Biosynthesis of marine natural products: microorganisms (Part A)
BS Moore
NATURAL PRODUCT REPORTS (2005)
Context-dependent behavior of the enterocin iterative polyketide synthase: A new model for ketoreduction
C Hertweck et al.
CHEMISTRY & BIOLOGY (2004)
Polyketide and nonribosomal peptide antibiotics: Modularity and versatility
CT Walsh
SCIENCE (2004)
Crystal structure and mechanism of a bacterial fluorinating enzyme
CJ Dong et al.
NATURE (2004)
The role of vanadium bromoperoxidase in the biosynthesis of halogenated marine natural products
A Butler et al.
NATURAL PRODUCT REPORTS (2004)
Natural organohalogens: a new frontier for medicinal agents?
GW Gribble
JOURNAL OF CHEMICAL EDUCATION (2004)
Lyngbyatoxin biosynthesis: Sequence of biosynthetic gene cluster and identification of a novel aromatic prenyltransferase
DJ Edwards et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
Genetic evidence supports secondary metabolic diversity in Prochloron spp., the cyanobacterial symbiont of a tropical ascidian
EW Schmidt et al.
JOURNAL OF NATURAL PRODUCTS (2004)
Marine natural products and related compounds in clinical and advanced preclinical trials
DJ Newman et al.
JOURNAL OF NATURAL PRODUCTS (2004)
Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula
ZX Chang et al.
JOURNAL OF NATURAL PRODUCTS (2004)
Vanadium bromoperoxidase-catalyzed biosynthesis of halogenated marine natural products
JN Carter-Franklin et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei
J Piel et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
EncM, a versatile enterocin biosynthetic enzyme involved in Favorskii oxidative rearrangement, aldol condensation, and heterocycle-forming reactions
L Xiang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Psymberin, a potent sponge-derived cytotoxin from Psammocinia distantly related to the pederin family
RH Cichewicz et al.
ORGANIC LETTERS (2004)
Characterization of the nodularin synthetase gene cluster and proposed theory of the evolution of cyanobacterial hepatotoxins
MC Moffitt et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2004)
Metabolites from symbiotic bacteria
J Piel
NATURAL PRODUCT REPORTS (2004)
Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula
DJ Edwards et al.
CHEMISTRY & BIOLOGY (2004)
Biosynthesis of nonribosomal peptides
R Finking et al.
ANNUAL REVIEW OF MICROBIOLOGY (2004)
Mutasynthesis of enterocin and wailupemycin analogues
JA Kalaitzis et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)
Nonribosomal peptides from marine sponges
S Matsunaga et al.
CURRENT ORGANIC CHEMISTRY (2003)
Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis
H Ikeda et al.
NATURE BIOTECHNOLOGY (2003)
Diversity of the biosynthesis of the isoprene units
T Kuzuyama et al.
NATURAL PRODUCT REPORTS (2003)
Characterization of benzoyl coenzyme a biosynthesis genes in the enterocin-producing bacterium Streptomyces maritimus
LK Xiang et al.
JOURNAL OF BACTERIOLOGY (2003)
Salinosporamide A: A highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus Salinospora
RH Feling et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2003)
A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles
J Piel
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Inactivation, complementation, and heterologous expression of encP, a novel bacterial phenylalanine ammonia-lyase gene
LK Xiang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
A gene cluster from a marine Streptomyces encoding the biosynthesis of the aromatic spiroketal polyketide griseorhodin A
AY Li et al.
CHEMISTRY & BIOLOGY (2002)
Molecular evidence for a uniform microbial community in sponges from different oceans
U Hentschel et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2002)
The barbamide biosynthetic gene cluster: a novel marine cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit
ZX Chang et al.
GENE (2002)
Structure and regulation of the omega-3 polyunsaturated fatty acid synthase genes from the deep-sea bacterium Photobacterium profundum strain SS9
EE Allen et al.
MICROBIOLOGY-SGM (2002)
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)
SD Bentley et al.
NATURE (2002)
Localization studies of bioactive cyclic peptides in the ascidian Lissoclinum patella
CE Salomon et al.
JOURNAL OF NATURAL PRODUCTS (2002)
Mutational analysis of the enterocin Favorskii biosynthetic rearrangement
LK Xiang et al.
ORGANIC LETTERS (2002)
The Pfam Protein Families Database
A Bateman et al.
NUCLEIC ACIDS RESEARCH (2002)
GeneMarkS: a self-training method for prediction of gene starts in microbial genomes. Implications for finding sequence motifs in regulatory regions
J Besemer et al.
NUCLEIC ACIDS RESEARCH (2001)
TIGRFAMs: a protein family resource for the functional identification of proteins
DH Haft et al.
NUCLEIC ACIDS RESEARCH (2001)
Polyketide biosynthesis: a millennium review
J Staunton et al.
NATURAL PRODUCT REPORTS (2001)
Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus':: evidence for the derailment of an aromatic polyketide synthase
J Piel et al.
CHEMISTRY & BIOLOGY (2000)
Biosynthesis of fatty acids in the docosahexaenoic acid-producing bacterium Moritella marina strain MP-I
N Morita et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2000)
Biosynthetic pathway and origin of the chlorinated methyl group in barbamide and dechlorobarbamide, metabolites from the marine cyanobacterium Lyngbya majuscula
N Sitachitta et al.
TETRAHEDRON (2000)
Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806:: an integrated peptide-polyketide synthetase system
D Tillett et al.
CHEMISTRY & BIOLOGY (2000)
Natural metabolic diversity encoded by the enterocin biosynthesis gene cluster
J Piel et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2000)
Highlights of marine natural products chemistry (1972-1999)
DJ Faulkner
NATURAL PRODUCT REPORTS (2000)