Journal
NATURAL PRODUCT REPORTS
Volume 28, Issue 11, Pages 1854-1867Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1np00048a
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Funding
- European Research Council under the European Union [(FP7/2007-2013)/ERC, 258413]
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Syrbactin is a subordinate term for the syringolin, glidobactin and cepafungin natural product families. Their grouping is based on their related molecular frameworks, similar biosynthesis pathways and, most importantly, identical modes-of-action, being irreversible proteasome inhibition. With this report, we aim to review their chemical biology, describing their common, but also differential characteristics.
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