Journal
NATURAL PRODUCT REPORTS
Volume 27, Issue 1, Pages 57-78Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b909987p
Keywords
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Funding
- Deutsche Forschungsgemeinschaft
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Prenylated indole alkaloids are hybrid natural products derived from prenyl diphosphates and tryptophan or its precursors and widely distributed in filamentous fungi, especially in the genera Penicillium and Aspergillus of ascomycota. These compounds represent a group of natural products with diverse chemical structures and biological activities. Significant progress on their biosynthesis has been achieved in recent years by identification of biosynthetic gene clusters from genome sequences and by molecular biological and biochemical investigations. In addition, a series of prenylated indole derivatives have been produced by chemoenzymatic synthesis using overproduced and purified enzymes.
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