Journal
NATURAL PRODUCT REPORTS
Volume 26, Issue 8, Pages 987-1000Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b904543k
Keywords
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Funding
- National Institutes of Health [GM20011, GM49338]
- Human Frontier Science Program
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM020011, F32GM020011, R37GM020011, P01GM047467, R01GM049338] Funding Source: NIH RePORTER
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Nonribosomal peptides have a variety of medicinal activities including activity as antibiotics, antitumor drugs, immunosuppressives, and toxins. Their biosynthesis on multimodular assembly lines as a series of covalently tethered thioesters, in turn covalently attached on pantetheinyl arms on carrier protein way stations, reflects similar chemical logic and protein machinery to fatty acid and polyketide biosynthesis. While structural information on excised or isolated catalytic adenylation (A), condensation (C), peptidyl carrier protein (PCP) and thioesterase (TE) domains had been gathered over the past decade, little was known about how the NRPS catalytic and carrier domains interact with each other both within and across elongation or termination modules. This Highlight reviews recent breakthrough achievements in both X-ray and NMR spectroscopic studies that illuminate the architecture of NRPS PCP domains, PCP-containing didomain-fragments and of a full termination module (C-A-PCP-TE).
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