Journal
NATURAL PRODUCT REPORTS
Volume 26, Issue 11, Pages 1488-1503Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b817078a
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Funding
- NIH [GM 077516, GM 071425]
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Bacterial cultivation has been a mainstay of natural products discovery for the past 80 years. However, the majority of bacteria are recalcitrant to culture, providing an untapped source for new natural products. Metagenomic analysis provides an alternative method to directly access the uncultivated genome for natural products research and for the discovery of novel, bioactive substances. Applications of metagenomics to diverse habitats, such as soils and the interior of animals, are described.
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