Journal
NATURAL PRODUCT REPORTS
Volume 25, Issue 6, Pages 1091-1117Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b616489g
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Funding
- The University of East Anglia
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Actinomycetes produce mycothiol as their major low molecular weight thiol, which parallels the functions of glutathione found in prokaryotes and most Gram-negative bacteria. This review covers progress that has so far been made in terms of its distribution, biosynthesis and metabolic functions, as well as chemical syntheses of mycothiol and alternative substrates and inhibitors of mycothiol biosynthesis and mycothiol-dependent enzymes. 152 references are cited.
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