Journal
NANOTOXICOLOGY
Volume 6, Issue 1, Pages 36-46Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/17435390.2011.552811
Keywords
Gold NP; gavage; absorption; gastro-intestinal tract; in vivo biodistribution
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Funding
- German Research Foundation [FOR 627, SPP 1313, PAK 56]
- EU [012912, NMP4-SL- 2008-214547]
- ENPRA [NMP4-SL-2009-228789]
- InLIveTox [NMP-2008-1.3-2 CP-FP 228625-2]
- US-NIH [HL074022]
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It is of urgent need to identify the exact physico-chemical characteristics which allow maximum uptake and accumulation in secondary target organs of nanoparticulate drug delivery systems after oral ingestion. We administered radiolabelled gold nanoparticles in different sizes (1.4-200 nm) with negative surface charge and 2.8 nm nanoparticles with opposite surface charges by intra-oesophageal instillation into healthy adult female rats. The quantitative amount of the particles in organs, tissues and excrements was measured after 24 h by gamma-spectroscopy. The highest accumulation in secondary organs was mostly found for 1.4 nm particles; the negatively charged particles were accumulated mostly more than positively charged particles. Importantly, 18 nm particles show a higher accumulation in brain and heart compared to other sized particles. No general rule accumulation can be made so far. Therefore, specialized drug delivery systems via the oral route have to be individually designed, depending on the respective target organ.
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