Journal
NANOTOXICOLOGY
Volume 6, Issue 4, Pages 414-423Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/17435390.2011.583996
Keywords
Nano-Ag; neurons; mEPSCs; sEPSCs; spontaneous action potential
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Funding
- National Natural Science Foundation of China [31000509, 31070890]
- UK Royal Academy of Engineering [5502]
- EPSRC [EP/D07942X/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/D07942X/1] Funding Source: researchfish
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The aim of this study was to investigate the actions of silver nanoparticles (nano-Ag) on glutamatergic synaptic transmission and excitability in hippocampal CA1 pyramidal neurons with whole cell patch technique. The amplitude of miniature excitatory postsynaptic currents (mEPSCs) was inhibited by silver nano-particles (nano-Ag) (10(-5) g/ml and 10(-4) g/ml), but the amplitude and frequency of spontaneous excitatory postsynaptic currents (sEPSCs) were increased by nano-Ag treatment (10(-5) g/ml and 10(-4) g/ml). Furthermore, nano-Ag (10(-5) g/ml and 10(-4) g/ml) increased the spontaneous network activity. These results provide further insights into the underlying mechanisms responsible for the effects of nano-Ag on central nervous system (CNS).
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