Journal
NANOTOXICOLOGY
Volume 3, Issue 2, Pages 161-U115Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/17435390902788086
Keywords
Cerium oxide nanoparticle; genotoxicity; cell; oxidative stress; redox
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Funding
- ANR
- INSU (French National Institute for Earth Sciences and Astronomy)
- Div Of Biological Infrastructure
- Direct For Biological Sciences [830093] Funding Source: National Science Foundation
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Cerium dioxide nanoparticles have been proposed for an increasing number of applications in biomedicine, cosmetic, as polishing materials and also as byproducts from automotive fuel additives. The aim of this study was to examine the potential in vitro cyto- and genotoxicity of nano-sized CeO2 (7 nm) on human dermal fibroblasts. By combining a physicochemical and a (geno)toxicological approach, we defined the causal mechanisms linking the physico-chemical properties of nano-CeO2 with their biological effects. Using X-ray absorption spectroscopy, we observed a reduction of 21 +/- 4% of the Ce4+ atoms localized at the surface of CeO2 nanoparticles due to the interactions with organic molecules present in biological media. These particles induced strong DNA lesions and chromosome damage related to an oxidative stress. These genotoxic effects occurred at very low doses, which highlighted the importance of a genotoxicological approach during the assessment of the toxicity of nanoparticles.
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