Journal
NANOTECHNOLOGY
Volume 29, Issue 47, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/1361-6528/aadfa5
Keywords
fucoidan; graphene oxide; reduction; surface functionalization; cancer therapy
Funding
- Korea Institute of Science and Technology (KIST) Open Research Program (ORP)
- Basic Science Research Program [2014K1B1A1073716, 2016R1E1A1A01941202]
- Nano Material Technology Development Program [2016M3A7B4900119, 2016M3A7B4905619]
- National Research Foundation of Korea (NRF) - Ministry of Science and ICT [NRF-2016R1C1B1008090]
- Research Center Program of IBS (Institute for Basic Science) - Korean government [IBS-R008-D1]
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A therapeutic reduced graphene oxide (RGO) is synthesized by using fucoidan (Fu) as the reducing and surface functionalizing agent. The synthesized Fu-RGO exhibits promising characteristics for therapeutic applications such as high dispersity in aqueous media, biocompatibility, selective cytotoxicity to cancer cells, high loading capacity of the anticancer drug, and photothermal conversion effect. Therefore, Fu-GO is successfully harnessed as a combinatorial cancer treatment platform through bio-functional (Fu), chemo (doxorubicin (Dox)) and photothermal (RGO with near-infrared irradiation) modalities.
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