Journal
NANOTECHNOLOGY
Volume 25, Issue 12, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/0957-4484/25/12/125102
Keywords
breast cancer; targeted drug delivery; micelle; disulfiram; metastasis
Funding
- National Basic Research Program of China [2010CB934000, 2013CB932704, 2013CB932503]
- National Natural Science Foundation of China [81270047, 81373359]
- Shanghai Elitist Program [12nm0501300]
Ask authors/readers for more resources
Metastasis, the main cause of cancer related deaths, remains the greatest challenge in cancer treatment. Disulfiram (DSF), which has multi-targeted anti-tumor activity, was encapsulated into redox-sensitive shell crosslinked micelles to achieve intracellular targeted delivery and finally inhibit tumor growth and metastasis. The crosslinked micelles demonstrated good stability in circulation and specifically released DSF under a reductive environment that mimicked the intracellular conditions of tumor cells. As a result, the DSF-loaded redox-sensitive shell crosslinked micelles (DCMs) dramatically inhibited cell proliferation, induced cell apoptosis and suppressed cell invasion, as well as impairing tube formation of HMEC-1 cells. In addition, the DCMs could accumulate in tumor tissue and stay there for a long time, thereby causing significant inhibition of 4T1 tumor growth and marked prevention in lung metastasis of 4T1 tumors. These results suggested that DCMs could be a promising delivery system in inhibiting the growth and metastasis of breast cancer.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available