4.6 Article

Propulsion of liposomes using bacterial motors

Journal

NANOTECHNOLOGY
Volume 24, Issue 18, Pages -

Publisher

IOP PUBLISHING LTD
DOI: 10.1088/0957-4484/24/18/185103

Keywords

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Funding

  1. National Natural Science Foundation of China [61273346, 51176106]
  2. National Defense Major Fundamental Research Program of China [Cxx20110003]
  3. National Defense Key Fundamental Research Program of China [Axx20110005, Axx20132010]
  4. Specialized Research Fund for the Doctoral Program of Higher Education [20121101120009]
  5. Beijing Natural Science Foundation [4122049]
  6. National Defense Pre-Research Foundation of China [xxx5020303]
  7. National Defense Exploration Research Program of China [xxx1216]
  8. Excellent Young Scholars Research Fund of Beijing Institute of Technology
  9. Program for the Fundamental Research of Beijing Institute of Technology [3020012211219, 3020012251104]
  10. Program of Introducing Talents of Discipline to University, China [B08043]

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Here we describe the utilization of flagellated bacteria as actuators to propel spherical liposomes by attaching bacteria to the liposome surface. Bacteria were stably attached to liposomes using a cross-linking antibody. The effect of the number of attached bacteria on propulsion speed was experimentally determined. The effects of bacterial propulsion on the bacteria-antibody-liposome complex were stochastic. We demonstrated that liposomal mobility increased when bacteria were attached, and the propulsion speed correlated with the number of bacteria.

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