Journal
NANOTECHNOLOGY
Volume 24, Issue 21, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/0957-4484/24/21/214001
Keywords
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Funding
- Basic Science Research Program of the Korean Health Technology R&D Project of the Ministry for Health, Welfare, & Family Affairs, Republic of Korea [A101954]
- National Research Foundation of Korea (NRF)
- Korean government (MEST) [2009-0093432, 2012R1A2A2A01047402, 2012R1A1B3001831]
- Korea Health Promotion Institute [HI10C1911020013] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2012R1A2A2A01047402, 2009-0093432, 2012R1A1B3001831, 2009-0083512] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The principle, characteristics and applications of molecular imaging with terahertz electromagnetic waves are reviewed herein. The terahertz molecular imaging (TMI) technique uses nanoparticle probes to achieve dramatically enhanced sensitivity compared with that of conventional terahertz imaging. Surface plasmons, induced around the nanoparticles, raise the temperature of water in biological cells, and the temperature-dependent changes in the optical properties of water, which are large in the terahertz range, are measured differentially by terahertz waves. TMI has been applied to cancer diagnosis and nanoparticle drug delivery imaging. The technique is also compared with magnetic resonance imaging by using a dual-modality nanoparticle probe.
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