Journal
NANOTECHNOLOGY
Volume 24, Issue 37, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/0957-4484/24/37/375104
Keywords
-
Funding
- US Department of Energy-Basic Energy Sciences [DE-FG02-06ER64239]
- US Department of Defence Breast Cancer Research Concept Program [W81XWH-07-1-0563]
- Research Council of the University of Oklahoma Norman Campus
- University of Oklahoma Bioengineering Center
- Portuguese Science and Technology Foundation [SFRH/BD/38742/2007]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/38742/2007] Funding Source: FCT
Ask authors/readers for more resources
This paper focuses on the targeting of single-walled carbon nanotubes (SWNTs) for the treatment of breast cancer with minimal side effects using photothermal therapy. The human protein annexin V (AV) binds specifically to anionic phospholipids expressed externally on the surface of tumour cells and endothelial cells that line the tumour vasculature. A 2 h incubation of the SWNT-AV conjugate with proliferating endothelial cells followed by washing and near-infrared (NIR) irradiation at a wavelength of 980 nm was enough to induce significant cell death; there was no significant cell death with irradiation or the conjugate alone. Administration of the same conjugate i.v. in BALB/c female mice with implanted 4T1 murine mammary at a dose of 0.8 mg SWNT kg(-1) and followed one day later by NIR irradiation of the tumour at a wavelength of 980 nm led to complete disappearance of implanted 4T1 mouse mammary tumours for the majority of the animals by 11 days since the irradiation. The combination of the photothermal therapy with the immunoadjuvant cyclophosphamide resulted in increased survival. The in vivo results suggest the SWNT-AV/NIR treatment is a promising approach to treat breast cancer.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available