Journal
NANOTECHNOLOGY
Volume 23, Issue 46, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/0957-4484/23/46/465101
Keywords
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Funding
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2010-0023202, 2010-0019923]
- National Research Foundation of Korea [과C6A1905, 2010-0023202] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Heterogeneous stem-like populations within tumor tissues are the primary suspects in causing cancer recurrence and malignancy. It is essential to selectively kill these tumorigenic populations. We created a novel system for photothermally ablating specific cells from three-dimensional mammospheres. A CD44-positive subpopulation, with tumorigenic and self-renewal potential, spontaneously arises in MCF7 breast cancer cell-engineered mammospheres. Using anti-CD44 antibody-linked gold nanorods, which strongly absorb near infrared light and increase local temperature, we effectively targeted and photo-ablated atypical cells. This biomarker-specific photothermal ablation model, using a smart nanoplatform, is a promising new strategy for selectively killing cancer cells, while sparing normal tissues.
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