Journal
NANOTECHNOLOGY
Volume 22, Issue 49, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/0957-4484/22/49/494002
Keywords
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Funding
- Marie Curie Reintegration Grant [FP7-People-2007-4-3-IRG, 230929]
- MIT-Portugal program
- Portuguese Foundation for Science and Technology (FCT) [PTDC/SA-BEB/098468/2008, PTDC/CTM/099659/2008]
- Crioestaminal [CENTRO-01-0202-FEDER-005476]
- [SFRH/BD/35270/2007]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/35270/2007] Funding Source: FCT
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Nanoparticles (NPs) are very promising for the intracellular delivery of anticancer and immunomodulatory drugs, stem cell differentiation biomolecules and cell activity modulators. Although initial studies in the area of intracellular drug delivery have been performed in the delivery of DNA, there is an increasing interest in the use of other molecules to modulate cell activity. Herein, we review the latest advances in the intracellular-targeted delivery of short interference RNA, proteins and small molecules using NPs. In most cases, the drugs act at different cellular organelles and therefore the drug-containing NPs should be directed to precise locations within the cell. This will lead to the desired magnitude and duration of the drug effects. The spatial control in the intracellular delivery might open new avenues to modulate cell activity while avoiding side-effects.
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