Journal
NANOTECHNOLOGY
Volume 22, Issue 23, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/0957-4484/22/23/235101
Keywords
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Funding
- Ministry of Education, Science, and Technology [2011-0001316, 2010-0019153, 2010-0026100]
- KRCF
- National Research Foundation of Korea [2009-0093114, 2009-0074905, 2010-0026100, 2008-2004308] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Using live-cell imaging techniques we investigated concentration-dependent intracellular movements of fluorescence nanoparticles (NPs) in real-time after their entry into HeLa cells via incubation. Intracellular particle traces appeared to be a mixture of both random and fairly unidirectional movements of the particles. At rather low concentrations of NPs, a majority of the non-random intracellular particle trajectories are assumed to mostly go along microtubule networks after endocytosis, as evidenced from the inhibition test with nocodazole. On the other hand, as the concentrations of NPs increased, random motions were more frequently observed inside the cells.
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