Journal
NANOTECHNOLOGY
Volume 20, Issue 6, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/0957-4484/20/6/065101
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Funding
- National Institutes of Health [R01 EB006201]
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We have demonstrated for the first time the feasibility of multiplex detection using the surface-enhanced Raman scattering-based molecular sentinel ( MS) technology in a homogeneous solution. Two MS nanoprobes tagged with different Raman labels were used to detect the presence of the erbB-2 and ki-67 breast cancer biomarkers. The multiplexing capability of the MS technique was demonstrated by mixing the two MS nanoprobes and tested in the presence of single or multiple DNA targets.
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