Journal
NANOTECHNOLOGY
Volume 20, Issue 9, Pages -Publisher
IOP Publishing Ltd
DOI: 10.1088/0957-4484/20/9/095103
Keywords
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Funding
- NIH [EB002849]
- NSF [0546012, 0730503, 0725528]
- Directorate For Engineering
- Div Of Electrical, Commun & Cyber Sys [0725528] Funding Source: National Science Foundation
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [0546012] Funding Source: National Science Foundation
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [0730503] Funding Source: National Science Foundation
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We present a novel convergence of quantum-dot-mediated fluorescence resonance energy transfer (QD-FRET) and microfluidics, through which molecular interactions were precisely controlled and monitored using highly sensitive quantum-dot-mediated FRET. We demonstrate its potential in studying the kinetics of self-assembly of DNA polyplexes under laminar flow in real time with millisecond resolution. The integration of nanophotonics and microfluidics offers a powerful tool for elucidating the formation of polyelectrolyte polyplexes, which is expected to provide better control and synthesis of uniform and customizable polyplexes for future nucleic acid-based therapeutics.
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