Journal
NANOTECHNOLOGY
Volume 19, Issue 36, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/0957-4484/19/36/365603
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Funding
- Korea Evaluation Institute of Industrial Technology (KEIT) [B0008463] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2006-521-C00081, 과06B1508] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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For the application of superparamagnetic iron oxide nanoparticles in biomedical fields for target-specific purposes, they should be ultra small in diameter. We developed a simple one-step synthesis of surface modified ultra small superparamagnetic iron oxide nanoparticles (USPIONs) with an average particle diameter of 1.7 nm in a polar organic solvent. Polyethylene glycol diacid (PEG) surface modified USPIONs synthesized in triethylene glycol were nearly monodisperse in diameter and highly water-dispersible. The PEG surface modified USPIONs were tested for use as magnetic resonance (MR) contrast agents. They had a low r(2)/r(1) relaxivity ratio of 3.4 (r(1) = 4.46 and r(2) = 15.01 mM(-1) s(-1)) and showed clear dose-dependent T-1 and T-2 map images, indicating that they will be useful as both target-specific T-1 and T-2 MR contrast agents due to their ultra small size.
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