Journal
NANOSCALE
Volume 10, Issue 41, Pages 19568-19578Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8nr06116e
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Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of education, Science and Technology [2016R1A2A2A07005160, 2016R1D1A1B03934124, 2018R1D1A1B07043245]
- Korea Research Fellowship Program through the National Research Foundation of Korea (NRF) - Ministry of Science and ICT KRF [2016H1D3A1938077]
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In order to meet the unmet medical needs for effective cancer treatment, multifunctional nanocarriers based on iron oxide nanoparticles hold tremendous promise. Here we report a superparamagnetic iron oxide nanoparticles based hexa-functional nanosystem for synergistic cancer theranostic applications by offering active tumour targeting, accumulation and complementary imaging capability by combining magnetic resonance imaging as well as near-infrared fluorescence, magnetophotothermia and chemotherapy. The uniquely designed nanosystem exhibited a paramount increase in the antitumour efficacy through the simultaneous application of multiple thermal effects called magnetophotothermia, which outweighed the therapeutic efficacy of the current thermo-chemo therapies or stand-alone therapies. The active tumour-seeking property with prolonged tumour accumulation and complementary imaging capability with improved sensitivity and resolution also augments the therapeutic efficacy of the proposed nanosystem. Additionally, the work proposes a deep-learning-based tumour cell nuclei detection technique from H&E stained images in anticipation of providing much inspiration for the future of precision histology.
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