Journal
NANOSCALE
Volume 10, Issue 14, Pages 6402-6408Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8nr00693h
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Funding
- European Research Council through the Advanced Grant VERDI (ERC) [694160]
- Ministerio de Economia y Competitividad, (MEC), Spain [MAT2015-64831-R]
- MEC, Spain [BES-2013-064182]
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A novel smart hierarchical ultrasound-responsive mesoporous silica nanocarrier for cancer therapy is presented here. This dynamic nanosystem has been designed to display different surface characteristics during its journey towards tumor cells. Initially, the anticancer-loaded nanocarriers are shielded with a polyethylene glycol layer. Upon exposure to high frequency ultrasound, the polymer shell detaches from the nanoparticles, exposing a positively charged surface. This favors the internalization in human osteosarcoma cells, where the release of topotecan takes place, drastically enhancing the cytotoxic effect.
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