Journal
NANOSCALE
Volume 10, Issue 33, Pages 15632-15640Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8nr05015e
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Funding
- Hong Kong Baptist University [RC-ICRS/16-17/1B-CHE]
- Hong Kong Research Grants Council [HKBU 22301615]
- National Natural Science Foundation of China [NSFC 21728101]
- CAS-Croucher Funding Scheme for Joint Laboratories [CAS18204]
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Non-responsive emission enhancement is the disadvantage of upconversion nanomaterials (UCNM) when compared with conventional organic based agents for molecular imaging. We herein show a new strategy by conjugating NaGdF4:Yb3+,Er3+@NaGdF4 (UCNP) with peptides to achieve responsive UC emission enhancement upon binding to a targeted protein - EBNA1. EBNA1 is a well-known viral latent protein for the EBV-associated cancer. Peptide-coating of the functionalized core-shell nanoparticle diminishes upconverted emission intensity drastically. However, the peptide-coated UCNP shows selective and responsive UC emission enhancement via aggregation with the targeted protein. This phenomenon paves a new way for UCNM in molecular imaging.
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