4.8 Article

In situ gold nanoparticle growth on polydopamine-coated 3D-printed scaffolds improves osteogenic differentiation for bone tissue engineering applications: in vitro and in vivo studies

Journal

NANOSCALE
Volume 10, Issue 33, Pages 15447-15453

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c8nr04037k

Keywords

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Funding

  1. Korean Health Technology R&D Project, Ministry of Health Welfare [HI13C1527]
  2. Basic Science Research Program through the National Research Foundation of Korea fund, Ministry of Education [2016R1C1B2016624]
  3. Bio & Medical Technology Development Program of the National Research Foundation (NRF)
  4. Korean government (MSIP), Republic of Korea [2017M3A9E4048170]
  5. Korean government (MOHW), Republic of Korea [2017M3A9E4048170]

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In this study, we designed scaffolds coated with gold nanoparticles (GNPs) grown on a polydopamine (PDA) coating of a three-dimensional (3D) printed polycaprolactone (PCL) scaffold. Our results demonstrated that the scaffolds developed here may represent an innovative paradigm in bone tissue engineering by inducing osteogenesis as a means of remodeling and healing bone defects.

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