Journal
NANOSCALE
Volume 10, Issue 26, Pages 12356-12363Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8nr00446c
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Funding
- NSF of China [11374297, 61575194, 11674316, 11504371, 11471278, 11604331]
- Science and Technology Agency, Jilin Province [20170520113JH, 20170520112JH, 20170519002JH, 20180101222JC]
- State Key Laboratory of Luminescence and Applications
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Multimodality imaging-guided therapy based on lanthanide-doped upconversion nanoparticles (UCNPs) has become a trend in cancer theranostics. However, the overheating effect of 980 nm excitation in photodynamic therapy (PDT) and the difficulties in optimizing multimodality imaging integration within a single particle are still challenges. Herein, 800 nm driven NaErF4@NaLuF4 UCNPs have been explored for optimized multimodality imaging and near-infrared (NIR) triggered PDT. Our results confirmed that the optimal similar to 5 nm shell thickness can well balance the enhancement of upconversion luminescence and the attenuation of energy transfer efficiency from Er3+ towards a photosensitizer, to achieve efficient production of singlet oxygen (O-1(2)) for PDT under 800 nm excitation. Furthermore, the as-obtained NaErF4@NaLuF4 UCNPs showed effective and applicable performance for upconversion luminescence (UCL) imaging, X-ray computed tomography (CT), and high-field T-2 magnetic resonance imaging (MRI). This nanomaterial can serve as an excellent theranostic agent for multimodality imaging and image-guided therapy.
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