Journal
NANOSCALE
Volume 6, Issue 21, Pages 13119-13125Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4nr03213f
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Funding
- Ministry of Science and Technology (MOST) [NSC 100-2627-M-002-007, 101-2113-M-002-002-MY3]
- MOST [K2989]
- Department of Chemistry, National Taiwan University [101-R-4000]
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A simple hydrothermal method was applied to prepare carbon nanodots (C dots) from o-phenylenediamine (OPD). The C dots exhibit photoluminescence at 567 nm when excited at 420 nm. In the presence of Cu2+ ions, the colour of C dots changes from yellow to orange, with an increased PL intensity as a result of the formation of Cu(OPD) 2 complexes on the surfaces of C dots. The D-band to G-band ratios of C dots in the absence and presence of 80 nM Cu2+ ions are 1.31 and 4.75, respectively. The C dots allow the detection of Cu2+ ions with linearity over a concentration range of 2-80 nM, with a limit of detection of 1.8 nM at a signal-to-noise ratio of 3. The cell viability values of A549, MCF-10A, and MDA-MB-231 cells treated with 3 mu g mL(-1) of C dots are all greater than 99%, showing their great biocompatibility. Having great water dispersibility, photostability, chemical stability (against NaCl up to 0.5 M), great selectivity, and biocompatibility, the C dots have been employed for the localization of Cu2+ ions in the cancer cells (A549 cells) treated with 10 mu M Cu2+ ions.
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