Journal
NANOSCALE
Volume 6, Issue 18, Pages 10486-10494Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4nr03124e
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Funding
- Defense Threat Reduction Agency-Joint Science and Technology Office for Chemical and Biological Defense [HDTRA1-13-1-0002]
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Nanomachines offer considerable promise for the treatment of diseases. The ability of man-made nanomotors to rapidly deliver therapeutic payloads to their target destination represents a novel nanomedicine approach. Synthetic nanomotors, based on a multitude of propulsion mechanisms, have been developed over the past decade toward diverse biomedical applications. In this review article, we journey from the use of chemically powered drug-delivery nanovehicles to externally actuated (fuel-free) drug-delivery nanomachine platforms, and conclude with future prospects and challenges for such practical propelling drug-delivery systems. As future micro/nanomachines become more powerful and functional, these tiny devices are expected to perform more demanding biomedical tasks and benefit different drug delivery applications.
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