Journal
NANOSCALE
Volume 6, Issue 15, Pages 8878-8883Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4nr02312a
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [21001072, 21231004, 21201117]
- Innovation Program of the Shanghai Municipal Education Commission [13ZZ073]
- Science and Technology Commission of Shanghai Municipality [13NM1401100, 13NM1401101]
- Shanghai Rising-Star Program [14QA1401800]
- State Key Laboratory of Rare Earth Resource Utilization [RERU2014012]
Ask authors/readers for more resources
Folate receptors (FRs) are overexpressed on a variety of human cancer cells and tissues, including cancers of the breast, ovaries, endometrium, and brain. This over-expression of FRs can be used to target folate-linked imaging specifically to FR-expressing tumors. Fluorescence is emerging as a powerful new modality for molecular imaging in both the diagnosis and treatment of disease. Combining innovative molecular biology and chemistry, we prepared three kinds of folate-targeted up-conversion nanoparticles as imaging agents (UCNC-FA: UCNC-Er-FA, UCNC-Tm-FA, and UCNC-Er,Tm-FA). In vivo and in vitro toxicity studies showed that these nanoparticles have both good biocompatibility and low toxicity. Moreover, the up-conversion luminescence imaging indicated that they have good targeting to HeLa cells and can therefore serve as potential fluorescent contrast agents.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available