Journal
NANOSCALE
Volume 6, Issue 14, Pages 8274-8282Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4nr01826e
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Funding
- 973 program of MOST [2014CB845605]
- Special Project of National Major Scientific Equipment Development of China [2012YQ120060]
- NSFC [11104266, 11204302, 11304314, 51002151, U1305244, 21325104]
- Strategic Priority Research Program and Scientific Equipment Development Project of the CAS [XDA09030307, YZ201210]
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Lanthanide-doped upconversion nanoparticles (UCNPs) have recently shown great promise in photodynamic therapy (PDT). Herein, we report a facile strategy to fabricate an efficient NIR-triggered PDT system based on LiYF4:Yb/Er UCNPs coupled with a photosensitizer of a beta-carboxyphthalocyanine zinc (ZnPc-COOH) molecule via direct electrostatic interaction. Due to the close proximity between UCNPs and ZnPc-COOH, we achieved a high energy transfer efficiency of 96.3% from UCNPs to ZnPc-COOH, which facilitates a large production of cytotoxic singlet oxygen and thus an enhanced PDT efficacy. Furthermore, we demonstrate the high efficacy of such a NIR-triggered PDT agent for the inhibition of tumor growth both in vitro and in vivo, thereby revealing the great potential of the UCNP-based PDT systems as noninvasive NIR-triggered PDT agents for deep cancer therapy.
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